Reactome | p-S552-CARD11 [cytosol]

p-S552-CARD11 [cytosol]

Stable Identifier

R-HSA-202438

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphorylated CARMA1

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - TCR signaling (Homo sapiens)
    - Downstream TCR signaling (Homo sapiens)
      - Activation of IKK complex (Homo sapiens)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
      - Activation of TAK1-TAB2 complex (Homo sapiens)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
      - Auto-ubiquitination of TRAF6 (Homo sapiens)
        
        TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
      - Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
      - Interaction of Bcl10 to CARMA1 (Homo sapiens)
        
        Bcl10 bound to CARMA1 [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
      - Oligomerization of Bcl10 (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
        
        Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
      - Oligomerization of CARMA1 (Homo sapiens)
        
        Activated CARMA1 [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
      - Phosphorylation of Bcl10 (Homo sapiens)
        
        Bcl10 bound to CARMA1 [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
        
        Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
      - Phosphorylation of CARMA1 (Homo sapiens)
        
        Activated CARMA1 [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
      - Translocation of TRAF6 to CBM complex (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
        
        TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
      - Ubiquitination of NEMO by TRAF6 (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - C-type lectin receptors (CLRs) (Homo sapiens)
    - CLEC7A (Dectin-1) signaling (Homo sapiens)
      - Ubiquitination of NEMO by TRAF6 (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated NF-kB activation (Homo sapiens)
      - Ubiquitination of NEMO by TRAF6 (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        p-S552-CARD11 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BXL7 CARD11

Gene Names

CARD11, CARMA1

Chain

chain:1-1154

Reference Genes

BioGPS Gene:84433 CARD11

COSMIC (genes):CARD11 CARD11

CTD Gene:84433 CARD11

dbSNP Gene:84433 CARD11

ENSEMBL:ENSG00000198286 CARD11

ENSEMBL_homo_sapiens_GENE:ENSG00000198286.11 CARD11

HGNC:16393 CARD11

KEGG Gene (Homo sapiens):84433 CARD11

Monarch:84433 CARD11

NCBI Gene:84433 CARD11

OMIM:607210 CARD11

UCSC:Q9BXL7 CARD11

Reference Transcript

Other Identifiers

11723142_at

17054631

223514_PM_at

223514_at

3035991

3035992

3035994

3035998

3035999

3036000

3036001

3036003

3036006

3036008

3036009

3036011

3036013

3036016

3036021

3036023

3036027

3036029

3036030

3036031

3036032

3036033

3036034

3036035

3036036

3036037

3036038

3036042

3036043

3036060

52847_at

8137874

84433

A_23_P82324

GE83418

GO:0001772

GO:0002376

GO:0003824

GO:0004385

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0007155

GO:0007165

GO:0007249

GO:0012501

GO:0016020

GO:0016740

GO:0023052

GO:0030154

GO:0030183

GO:0030890

GO:0031295

GO:0032449

GO:0032743

GO:0035739

GO:0038202

GO:0042100

GO:0042110

GO:0042981

GO:0043123

GO:0043226

GO:0043621

GO:0045061

GO:0045121

GO:0045577

GO:0045580

GO:0046037

GO:0046649

GO:0046710

GO:0048856

GO:0048872

GO:0050700

GO:0050776

GO:0050862

GO:0050870

GO:0050896

GO:0051092

GO:0051260

GO:0055086

GO:0065003

GO:0070062

GO:1901135

GO:2000563

HMNXSV003003493

HMNXSV003016304

HMNXSV003035218

ILMN_1721978

PH_hs_0015270

TC07001102.hg

g12382772_3p_at

Participates

as a component of

as an input of

Oligomerization of CARMA1 (Homo sapiens)

Other forms of this molecule

CARD11 [plasma membrane]

p-S559,S652-CARD11 [cytosol]

p-S559,S644,S652-CARD11 [plasma membrane]

CARD11 [cytosol]

Inferred To

phospho-card11 [cytosol] (Xenopus tropicalis)

phospho-CARD11 [cytosol] (Bos taurus)

phospho-CARD11 [cytosol] (Canis familiaris)

phospho-CARD11 [cytosol] (Sus scrofa)

phospho-Card11 [cytosol] (Mus musculus)

phospho-Card11 [cytosol] (Rattus norvegicus)

phospho-p-S552-CARD11 [cytosol] (Gallus gallus)

Modified Residues

Name

O-phospho-L-serine at 559

Coordinate

559

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_115791.3, XP_011513888.1, NP_001311210.1

OpenTargets

ENSG00000198286

GeneCards

Q9BXL7

HPA

ENSG00000198286-CARD11

Ensembl

ENST00000396946, ENSP00000380150, ENSG00000198286

PRO

Q9BXL7

Pharos - Targets

Q9BXL7

Orphanet

22042

PDB

4LWD, 4JUP

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.857	7
UniProt:Q05655 PRKCD	12	PRKCD(1-676) [nucleoplasm] (R-HSA-450606) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) p-T507-PRKCD [cytosol] (R-HSA-5218746) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) PRKCD(330-676) [cytosol] (R-HSA-212551) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD [cytosol] (R-HSA-58200)	0.619	7
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.589	2
UniProt:Q13191-1 CBLB			0.524	4
IntAct:EBI-4399559 UBIQ			0.524	2
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.499	5
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.462	2

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