Caspase-8 binds MALT

Stable Identifier
R-HSA-5660665
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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After CLEC7A (dectin-1) triggering, MALT1 and caspase-8 associate to form BCL10-MALT1-Caspase-8 complex. MALT1 has a crucial dual role in the expression of IL1B by CLEC7A. It is involved in the transcription of IL1B by activating NF-kB and the other role in processing of pro-IL1B by mediating the formation and activation of a MALT1-caspase8-ASC (adaptor protein apoptosis-associated speck-like protein containing a CARD) complex (Gringhuis et al. 2012). The paracaspase domain of MALT1, in a protease-independent manner, induces caspase-8 activation through direct association (Kawadler et al. 2008).

Literature References
PubMed ID Title Journal Year
22267217 Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome

Gringhuis, SI, Kaptein, TM, Wevers, BA, Theelen, B, van der Vlist, M, Boekhout, T, Geijtenbeek, TB

Nat. Immunol. 2012
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