Reactome | RAB GEFs exchange GTP for GDP on RABs

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RAB GEFs exchange GTP for GDP on RABs Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
created	[InstanceEdit:8876197] Rothfels, Karen, 2016-06-09
dbId	8876198
displayName	RAB GEFs exchange GTP for GDP on RABs
doi	10.3180/R-HSA-8876198.1
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-9007101] Rab regulation of trafficking - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Homo sapiens [Reaction:R-HSA-8875318] RAB3 GEFs exchange GTP for GDP on RAB3A - Homo sapiens [Reaction:R-HSA-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Homo sapiens [Reaction:R-HSA-8876193] RIC1-RGP1 exchanges GTP for GDP on RAB6 - Homo sapiens [Reaction:R-HSA-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Homo sapiens [Reaction:R-HSA-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Homo sapiens [Reaction:R-HSA-8876191] RAB9 GEFs exchange GTP for GDP on RAB9 - Homo sapiens [Reaction:R-HSA-8876188] DENND4s exchange GTP for GDP on RAB10 - Homo sapiens [Reaction:R-HSA-8876446] p-ULK1 phosphorylates DENND3 - Homo sapiens [Reaction:R-HSA-8876454] DENND3 exchanges GTP for GDP on RAB12 - Homo sapiens [Reaction:R-HSA-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Homo sapiens [Reaction:R-HSA-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Homo sapiens [Reaction:R-HSA-8876837] RAB21 GEFs exchange GTP for GDP on RAB21 - Homo sapiens [Reaction:R-HSA-8877308] MADD exchanges GTP for GDP on RAB27 - Homo sapiens [Reaction:R-HSA-8877311] RAB31 GEFs exchange GTP for GDP on RAB31 - Homo sapiens [Reaction:R-HSA-8933446] Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling - Homo sapiens [Reaction:R-HSA-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Homo sapiens [Reaction:R-HSA-8877612] DENND1s exchange GTP for GDP on RAB35 - Homo sapiens [Reaction:R-HSA-8877760] HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 - Homo sapiens [Reaction:R-HSA-8877813] DENND5A,B exchange GTP for GDP on RAB39 - Homo sapiens [Reaction:R-HSA-8877998] RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8855098] Rab GTPases as coordinators of vesicle traffic [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system [LiteratureReference:8875688] Hypervariable C-terminal domain of rab proteins acts as a targeting signal [LiteratureReference:8874657] Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins [LiteratureReference:8874646] Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange [LiteratureReference:6801137] Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A [LiteratureReference:8874649] Nucleotide dependence of Rab geranylgeranylation. Rab escort protein interacts preferentially with GDP-bound Rab [LiteratureReference:8875709] Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes [LiteratureReference:8875704] Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy [LiteratureReference:8855099] TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism [LiteratureReference:8855100] Illuminating the functional and structural repertoire of human TBC/RABGAPs [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8874103] Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes [LiteratureReference:8874101] Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein [LiteratureReference:8870364] Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein [LiteratureReference:8875710] Protein prenylation: enzymes, therapeutics, and biotechnology applications [LiteratureReference:6801102] Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate [LiteratureReference:8875714] Yip3 catalyses the dissociation of endosomal Rab-GDI complexes [LiteratureReference:8867347] TBC proteins: GAPs for mammalian small GTPase Rab? [LiteratureReference:5672281] Regulation of small GTPases by GEFs, GAPs, and GDIs [LiteratureReference:8877950] Rab GEFs and GAPs [LiteratureReference:8877631] DENN domain proteins: regulators of Rab GTPases
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	RAB GEFs exchange GTP for GDP on RABs
orthologousEvent	[Pathway:R-PFA-8876198] RAB GEFs exchange GTP for GDP on RABs - Plasmodium falciparum [Pathway:R-SCE-8876198] RAB GEFs exchange GTP for GDP on RABs - Saccharomyces cerevisiae [Pathway:R-SPO-8876198] RAB GEFs exchange GTP for GDP on RABs - Schizosaccharomyces pombe [Pathway:R-DDI-8876198] RAB GEFs exchange GTP for GDP on RABs - Dictyostelium discoideum [Pathway:R-CEL-8876198] RAB GEFs exchange GTP for GDP on RABs - Caenorhabditis elegans [Pathway:R-DME-8876198] RAB GEFs exchange GTP for GDP on RABs - Drosophila melanogaster [Pathway:R-GGA-8876198] RAB GEFs exchange GTP for GDP on RABs - Gallus gallus [Pathway:R-XTR-8876198] RAB GEFs exchange GTP for GDP on RABs - Xenopus tropicalis [Pathway:R-DRE-8876198] RAB GEFs exchange GTP for GDP on RABs - Danio rerio [Pathway:R-MMU-8876198] RAB GEFs exchange GTP for GDP on RABs - Mus musculus [Pathway:R-RNO-8876198] RAB GEFs exchange GTP for GDP on RABs - Rattus norvegicus [Pathway:R-CFA-8876198] RAB GEFs exchange GTP for GDP on RABs - Canis familiaris [Pathway:R-BTA-8876198] RAB GEFs exchange GTP for GDP on RABs - Bos taurus [Pathway:R-SSC-8876198] RAB GEFs exchange GTP for GDP on RABs - Sus scrofa
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8876198
summation	[Summation:8878000] Human cells have more than 60 RAB proteins that are key regu...

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[Pathway:R-HSA-9007101] Rab regulation of trafficking

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