Reactome | TRAPPC complexes exchange GTP for GDP on RAB1

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TRAPPC complexes exchange GTP for GDP on RAB1 Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8877457] guanyl-nucleotide exchange factor activity of TRAPPCs [cytosol]
category	transition
compartment	[Compartment:13946] transport vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:8877474] Rothfels, Karen, 2016-06-22
dbId	8877475
displayName	TRAPPC complexes exchange GTP for GDP on RAB1
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input	[Complex:R-HSA-8877473] GGC-RAB1:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5688472] COPII and COPI traffic at the ER-Golgi interface [LiteratureReference:8877434] Rab proteins of the endoplasmic reticulum: functions and interactors [LiteratureReference:5685808] The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi [LiteratureReference:8877462] Rab1 in cell signaling, cancer and other diseases [LiteratureReference:5685801] TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 [LiteratureReference:5685817] mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles [LiteratureReference:5685780] Sequential interactions with Sec23 control the direction of vesicle traffic [LiteratureReference:5685749] In sickness and in health: the role of TRAPP and associated proteins in disease [LiteratureReference:8877429] The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes [LiteratureReference:8877426] TRAPP stimulates guanine nucleotide exchange on Ypt1p [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	TRAPPC complexes exchange GTP for GDP on RAB1
orthologousEvent	[Reaction:R-PFA-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Plasmodium falciparum [Reaction:R-SCE-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Saccharomyces cerevisiae [Reaction:R-SPO-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Schizosaccharomyces pombe [Reaction:R-DDI-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Dictyostelium discoideum [Reaction:R-CEL-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Caenorhabditis elegans [Reaction:R-DME-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Drosophila melanogaster [Reaction:R-BTA-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Bos taurus [Reaction:R-CFA-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Canis familiaris [Reaction:R-RNO-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Rattus norvegicus [Reaction:R-MMU-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Mus musculus
output	[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [CandidateSet:R-HSA-8877468] GGC-RAB1:GTP [transport vesicle membrane]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8877475
summation	[Summation:8877438] RAB1 is involved in COPII-mediated anterograde traffic from ...

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[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs

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