Reactome | RAB GEFs exchange GTP for GDP on RABs

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RAB GEFs exchange GTP for GDP on RABs Show undefined attributes

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050712
displayName	RAB GEFs exchange GTP for GDP on RABs
eventOf	[Pathway:R-DDI-9007101] Rab regulation of trafficking - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DDI-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Dictyostelium discoideum [Reaction:R-DDI-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Dictyostelium discoideum [Reaction:R-DDI-8876193] RIC1-RGP1 exchanges GTP for GDP on RAB6 - Dictyostelium discoideum [Reaction:R-DDI-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Dictyostelium discoideum [Reaction:R-DDI-8876191] RAB9 GEFs exchange GTP for GDP on RAB9 - Dictyostelium discoideum [Reaction:R-DDI-8876446] p-ULK1 phosphorylates DENND3 - Dictyostelium discoideum [Reaction:R-DDI-8876454] DENND3 exchanges GTP for GDP on RAB12 - Dictyostelium discoideum [Reaction:R-DDI-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Dictyostelium discoideum [Reaction:R-DDI-8876837] RAB21 GEFs exchange GTP for GDP on RAB21 - Dictyostelium discoideum [Reaction:R-DDI-8877311] RAB31 GEFs exchange GTP for GDP on RAB31 - Dictyostelium discoideum [Reaction:R-DDI-8877998] RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RAB GEFs exchange GTP for GDP on RABs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-8876198
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-9007101] Rab regulation of trafficking
(inferredTo)	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs

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