Reactome | DENND3 exchanges GTP for GDP on RAB12

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DENND3 exchanges GTP for GDP on RAB12 Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8876442] guanyl-nucleotide exchange factor activity of DENND3 [cytosol]
category	transition
compartment	[Compartment:262783] recycling endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:8876455] Rothfels, Karen, 2016-06-14
dbId	8876454
displayName	DENND3 exchanges GTP for GDP on RAB12
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input	[Complex:R-HSA-8876453] GCC-RAB12:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors [LiteratureReference:8876402] Dennd3 functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts [LiteratureReference:8876410] Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy [LiteratureReference:8876440] DENND3: a signaling/trafficking interface in autophagy [LiteratureReference:8876427] Small GTPase Rab12 regulates constitutive degradation of transferrin receptor [LiteratureReference:8876411] Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4 [LiteratureReference:8876406] M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells [LiteratureReference:8876418] PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified	[InstanceEdit:10871105] Wright, Adam, 2024-03-08
name	DENND3 exchanges GTP for GDP on RAB12
orthologousEvent	[Reaction:R-SPO-8876454] DENND3 exchanges GTP for GDP on RAB12 - Schizosaccharomyces pombe [Reaction:R-DDI-8876454] DENND3 exchanges GTP for GDP on RAB12 - Dictyostelium discoideum [Reaction:R-GGA-8876454] DENND3 exchanges GTP for GDP on RAB12 - Gallus gallus [Reaction:R-SSC-8876454] DENND3 exchanges GTP for GDP on RAB12 - Sus scrofa [Reaction:R-BTA-8876454] DENND3 exchanges GTP for GDP on RAB12 - Bos taurus [Reaction:R-CFA-8876454] DENND3 exchanges GTP for GDP on RAB12 - Canis familiaris [Reaction:R-RNO-8876454] DENND3 exchanges GTP for GDP on RAB12 - Rattus norvegicus [Reaction:R-MMU-8876454] DENND3 exchanges GTP for GDP on RAB12 - Mus musculus
output	[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-8876448] GGC-RAB12:GTP [recycling endosome membrane]
precedingEvent	[Reaction:R-HSA-8876446] p-ULK1 phosphorylates DENND3 - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8876454
summation	[Summation:8876433] DENND3 is a RAB12-specific GEF with roles in macroautophagy ...

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(hasEvent)

[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs

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