Reactome | YWHAE dimer binds phosphorylated DENND1 proteins

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YWHAE dimer binds phosphorylated DENND1 proteins Show undefined attributes

authored	[InstanceEdit:8933243] Rothfels, Karen, 2016-08-04
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8933451] Rothfels, Karen, 2016-08-04
dbId	8933452
displayName	YWHAE dimer binds phosphorylated DENND1 proteins
edited	[InstanceEdit:8933243] Rothfels, Karen, 2016-08-04
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
followingEvent	[Reaction:R-HSA-8877612] DENND1s exchange GTP for GDP on RAB35 - Homo sapiens
input	[CandidateSet:R-HSA-8933377] p-2S DENND1A, DENND1B [cytosol] [Complex:R-HSA-194364] YWHAE dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8933343] Phosphorylation-dependent Regulation of Connecdenn/DENND1 Guanine Nucleotide Exchange Factors [LiteratureReference:8854273] TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes [LiteratureReference:8933338] Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	YWHAE dimer binds phosphorylated DENND1 proteins
orthologousEvent	[Reaction:R-DME-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Drosophila melanogaster [Reaction:R-GGA-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Gallus gallus [Reaction:R-XTR-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Xenopus tropicalis [Reaction:R-SSC-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Sus scrofa [Reaction:R-BTA-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Bos taurus [Reaction:R-CFA-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Canis familiaris [Reaction:R-RNO-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Rattus norvegicus [Reaction:R-MMU-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Mus musculus
output	[Complex:R-HSA-8933379] p-2S-DENND1A,B:YWHAE dimer [cytosol]
precedingEvent	[Reaction:R-HSA-8933446] Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8933452
summation	[Summation:8933396] RAB35 GEFs DENND1A and DENND1B are phosphorylated by AKT in ...

Referrals

(precedingEvent)	[Reaction:R-HSA-8877612] DENND1s exchange GTP for GDP on RAB35
(hasEvent)	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs