Reactome | DENND1s exchange GTP for GDP on RAB35

Schema > Reaction > Entries

DENND1s exchange GTP for GDP on RAB35 Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8877609] guanyl-nucleotide exchange factor activity of RAB35 GEFs [cytosol]
category	transition
compartment	[Compartment:262783] recycling endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:8877611] Rothfels, Karen, 2016-06-24
dbId	8877612
displayName	DENND1s exchange GTP for GDP on RAB35
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input	[Complex:R-HSA-8877604] GGC-RAB35:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6814826] Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [LiteratureReference:8877653] The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes [LiteratureReference:8854201] Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis [LiteratureReference:8877645] Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis [LiteratureReference:8877635] MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a [LiteratureReference:8854294] Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C [LiteratureReference:8854203] Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins [LiteratureReference:8854200] Rab35 controls actin bundling by recruiting fascin as an effector protein [LiteratureReference:8854273] TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes [LiteratureReference:8933338] Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2 [LiteratureReference:8877649] Rab35 GTPase: a central regulator of phosphoinositides and F-actin in endocytic recycling and beyond [LiteratureReference:8877651] Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein [LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors [LiteratureReference:8876575] Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton [LiteratureReference:8877655] The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery [LiteratureReference:8877631] DENN domain proteins: regulators of Rab GTPases [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8875693] Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	DENND1s exchange GTP for GDP on RAB35
orthologousEvent	[Reaction:R-DDI-8877612] DENND1s exchange GTP for GDP on RAB35 - Dictyostelium discoideum [Reaction:R-CEL-8877612] DENND1s exchange GTP for GDP on RAB35 - Caenorhabditis elegans [Reaction:R-DME-8877612] DENND1s exchange GTP for GDP on RAB35 - Drosophila melanogaster [Reaction:R-GGA-8877612] DENND1s exchange GTP for GDP on RAB35 - Gallus gallus [Reaction:R-XTR-8877612] DENND1s exchange GTP for GDP on RAB35 - Xenopus tropicalis [Reaction:R-SSC-8877612] DENND1s exchange GTP for GDP on RAB35 - Sus scrofa [Reaction:R-BTA-8877612] DENND1s exchange GTP for GDP on RAB35 - Bos taurus [Reaction:R-CFA-8877612] DENND1s exchange GTP for GDP on RAB35 - Canis familiaris [Reaction:R-RNO-8877612] DENND1s exchange GTP for GDP on RAB35 - Rattus norvegicus [Reaction:R-MMU-8877612] DENND1s exchange GTP for GDP on RAB35 - Mus musculus
output	[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-8877601] GGC-RAB35:GTP [recycling endosome membrane]
precedingEvent	[Reaction:R-HSA-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8877612
summation	[Summation:8877658] RAB35 localizes to the plasma membrane, to clathrin-coated v...

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(hasEvent)

[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs

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