Reactome | RAB8 GEFs exchange GTP for GDP on RAB8

Schema > Reaction > Entries

RAB8 GEFs exchange GTP for GDP on RAB8 Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8876173] guanyl-nucleotide exchange factor activity of RAB8 GEFs [cytosol]
category	transition
compartment	[Compartment:263163] trans-Golgi network membrane [Compartment:70101] cytosol
created	[InstanceEdit:8876189] Rothfels, Karen, 2016-06-09
dbId	8876190
displayName	RAB8 GEFs exchange GTP for GDP on RAB8
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input	[Complex:R-HSA-8876120] GGC-RAB8:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8876170] Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane [LiteratureReference:1458557] Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells [LiteratureReference:1458569] Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation [LiteratureReference:1449646] Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells [LiteratureReference:5617505] A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis [LiteratureReference:5617564] Functional dissection of Rab GTPases involved in primary cilium formation [LiteratureReference:5625323] The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization [LiteratureReference:1458661] Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis [LiteratureReference:2562529] Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression [LiteratureReference:5623283] A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport [LiteratureReference:5623281] A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis [LiteratureReference:5623298] Coordination of Rab8 and Rab11 in primary ciliogenesis [LiteratureReference:5623312] Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome [LiteratureReference:5623329] The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting [LiteratureReference:5618172] The roles of evolutionarily conserved functional modules in cilia-related trafficking [LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	RAB8 GEFs exchange GTP for GDP on RAB8
orthologousEvent	[Reaction:R-SCE-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Saccharomyces cerevisiae [Reaction:R-SPO-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Schizosaccharomyces pombe [Reaction:R-CEL-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Caenorhabditis elegans [Reaction:R-GGA-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Gallus gallus [Reaction:R-XTR-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Xenopus tropicalis [Reaction:R-DRE-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Danio rerio [Reaction:R-SSC-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Sus scrofa [Reaction:R-BTA-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Bos taurus [Reaction:R-CFA-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Canis familiaris [Reaction:R-RNO-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Rattus norvegicus [Reaction:R-MMU-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Mus musculus
output	[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-8876116] GGC-RAB8:GTP [trans-Golgi network membrane]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8876190
summation	[Summation:8876186] RAB8 is involved in trafficking from the trans-Golgi network...

Referrals

(hasEvent)

[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs

Cite Us!