Reactome | DENND4s exchange GTP for GDP on RAB10

Schema > Reaction > Entries

DENND4s exchange GTP for GDP on RAB10 Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8876171] guanyl-nucleotide exchange factor activity of DENND4s [cytosol]
category	transition
compartment	[Compartment:437051] cytoplasmic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:8876187] Rothfels, Karen, 2016-06-09
dbId	8876188
displayName	DENND4s exchange GTP for GDP on RAB10
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input	[Complex:R-HSA-8876131] GGC-RAB10:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8876134] Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag [LiteratureReference:8876164] Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells [LiteratureReference:8876157] Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells [LiteratureReference:2457782] Rab10 in insulin-stimulated GLUT4 translocation [LiteratureReference:8876145] Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes [LiteratureReference:8876151] Rab10 delivers GLUT4 storage vesicles to the plasma membrane [LiteratureReference:8876143] Rab10 GTPase regulates ER dynamics and morphology [LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	DENND4s exchange GTP for GDP on RAB10
orthologousEvent	[Reaction:R-CEL-8876188] DENND4s exchange GTP for GDP on RAB10 - Caenorhabditis elegans [Reaction:R-DME-8876188] DENND4s exchange GTP for GDP on RAB10 - Drosophila melanogaster [Reaction:R-GGA-8876188] DENND4s exchange GTP for GDP on RAB10 - Gallus gallus [Reaction:R-XTR-8876188] DENND4s exchange GTP for GDP on RAB10 - Xenopus tropicalis [Reaction:R-SSC-8876188] DENND4s exchange GTP for GDP on RAB10 - Sus scrofa [Reaction:R-BTA-8876188] DENND4s exchange GTP for GDP on RAB10 - Bos taurus [Reaction:R-CFA-8876188] DENND4s exchange GTP for GDP on RAB10 - Canis familiaris [Reaction:R-RNO-8876188] DENND4s exchange GTP for GDP on RAB10 - Rattus norvegicus [Reaction:R-MMU-8876188] DENND4s exchange GTP for GDP on RAB10 - Mus musculus
output	[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-8876128] GGC-RAB10:GTP [cytoplasmic vesicle membrane]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8876188
summation	[Summation:8876180] RAB10 has well characterized roles in basolateral sorting an...

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[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs

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