Reactome | MADD exchanges GTP for GDP on RAB27

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MADD exchanges GTP for GDP on RAB27 Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8877307] guanyl-nucleotide exchange factor activity of MADD [cytosol]
category	transition
compartment	[Compartment:5668575] melanosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:8877306] Rothfels, Karen, 2016-06-21
dbId	8877308
displayName	MADD exchanges GTP for GDP on RAB27
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input	[Complex:R-HSA-8877298] GGC-RAB27:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8877196] Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets [LiteratureReference:8877242] Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes [LiteratureReference:8877240] Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding [LiteratureReference:8877230] Rab27 effectors, pleiotropic regulators in secretory pathways [LiteratureReference:8877246] Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans [LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	MADD exchanges GTP for GDP on RAB27
orthologousEvent	[Reaction:R-CEL-8877308] MADD exchanges GTP for GDP on RAB27 - Caenorhabditis elegans [Reaction:R-DME-8877308] MADD exchanges GTP for GDP on RAB27 - Drosophila melanogaster [Reaction:R-GGA-8877308] MADD exchanges GTP for GDP on RAB27 - Gallus gallus [Reaction:R-SSC-8877308] MADD exchanges GTP for GDP on RAB27 - Sus scrofa [Reaction:R-BTA-8877308] MADD exchanges GTP for GDP on RAB27 - Bos taurus [Reaction:R-CFA-8877308] MADD exchanges GTP for GDP on RAB27 - Canis familiaris [Reaction:R-RNO-8877308] MADD exchanges GTP for GDP on RAB27 - Rattus norvegicus [Reaction:R-MMU-8877308] MADD exchanges GTP for GDP on RAB27 - Mus musculus
output	[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [CandidateSet:R-HSA-8877303] RAB27:GTP [melanosome membrane]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8877308
summation	[Summation:8877305] Vertebrate RAB27 exists in two isoforms, RAB27A and RAB27B, ...

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[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs