Reactome | RAB5 GEFs exchange GTP for GDP on RAB5

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RAB5 GEFs exchange GTP for GDP on RAB5 Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8875325] guanyl-nucleotide exchange factor activity of RAB5 GEFs [cytosol]
category	transition
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:8875322] Rothfels, Karen, 2016-06-02
dbId	8875320
displayName	RAB5 GEFs exchange GTP for GDP on RAB5
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input	[Complex:R-HSA-8875330] GGC-RAB5:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8871102] Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments [LiteratureReference:8875274] The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway [LiteratureReference:8875286] rab5 controls early endosome fusion in vitro [LiteratureReference:8875193] A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion [LiteratureReference:8875269] Rab5 is necessary for the biogenesis of the endolysosomal system in vivo [LiteratureReference:8868162] A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis [LiteratureReference:8875276] Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1 [LiteratureReference:444728] Molecular cloning and characterization of prokineticin receptors [LiteratureReference:8875257] RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway [LiteratureReference:8875222] Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31 [LiteratureReference:8875244] Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking [LiteratureReference:8875214] ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics [LiteratureReference:8871109] Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis [LiteratureReference:8875208] ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics [LiteratureReference:8875417] A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	RAB5 GEFs exchange GTP for GDP on RAB5
orthologousEvent	[Reaction:R-PFA-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Plasmodium falciparum [Reaction:R-SCE-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Saccharomyces cerevisiae [Reaction:R-SPO-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Schizosaccharomyces pombe [Reaction:R-DDI-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Dictyostelium discoideum [Reaction:R-CEL-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Caenorhabditis elegans [Reaction:R-DME-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Drosophila melanogaster [Reaction:R-GGA-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Gallus gallus [Reaction:R-DRE-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Danio rerio [Reaction:R-SSC-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Sus scrofa [Reaction:R-BTA-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Bos taurus [Reaction:R-CFA-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Canis familiaris [Reaction:R-RNO-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Rattus norvegicus [Reaction:R-MMU-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Mus musculus
output	[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-8875316] GGC-RAB5:GTP [early endosome membrane]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8875320
summation	[Summation:8875315] RAB5 has roles at early endosomal compartments including fus...

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[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs

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