Reactome | p-ULK1 phosphorylates DENND3

Schema > Reaction > Entries

p-ULK1 phosphorylates DENND3 Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8876445] protein serine/threonine kinase activity of p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8876444] Rothfels, Karen, 2016-06-14
dbId	8876446
displayName	p-ULK1 phosphorylates DENND3
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
followingEvent	[Reaction:R-HSA-8876454] DENND3 exchanges GTP for GDP on RAB12 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-8876435] DENND3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5672133] The ULK1 complex: sensing nutrient signals for autophagy activation [LiteratureReference:8876411] Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4 [LiteratureReference:8876402] Dennd3 functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts [LiteratureReference:8876410] Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy [LiteratureReference:8876418] PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer [LiteratureReference:8876427] Small GTPase Rab12 regulates constitutive degradation of transferrin receptor [LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors [LiteratureReference:8876569] Endocytosis and autophagy: Shared machinery for degradation [LiteratureReference:8876440] DENND3: a signaling/trafficking interface in autophagy
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	p-ULK1 phosphorylates DENND3
orthologousEvent	[Reaction:R-SPO-8876446] p-ULK1 phosphorylates DENND3 - Schizosaccharomyces pombe [Reaction:R-DDI-8876446] p-ULK1 phosphorylates DENND3 - Dictyostelium discoideum [Reaction:R-GGA-8876446] p-ULK1 phosphorylates DENND3 - Gallus gallus [Reaction:R-SSC-8876446] p-ULK1 phosphorylates DENND3 - Sus scrofa [Reaction:R-BTA-8876446] p-ULK1 phosphorylates DENND3 - Bos taurus [Reaction:R-CFA-8876446] p-ULK1 phosphorylates DENND3 - Canis familiaris [Reaction:R-RNO-8876446] p-ULK1 phosphorylates DENND3 - Rattus norvegicus [Reaction:R-MMU-8876446] p-ULK1 phosphorylates DENND3 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-8876434] p-S472,S490-DENND3 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-5672008] Thr-180 of ULK1 is phosphorylated - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8876446
summation	[Summation:8876430] ULK1 is a serine-threonine kinase with key roles in macroaut...

Referrals

(hasEvent)	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs
(precedingEvent)	[Reaction:R-HSA-8876454] DENND3 exchanges GTP for GDP on RAB12

Cite Us!