Reactome | DENND6A,B exchange GTP for GDP on RAB14

Schema > Reaction > Entries

DENND6A,B exchange GTP for GDP on RAB14 Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8876612] guanyl-nucleotide exchange factor activity of DENND6A,B [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:262783] recycling endosome membrane
created	[InstanceEdit:8876613] Rothfels, Karen, 2016-06-15
dbId	8876616
displayName	DENND6A,B exchange GTP for GDP on RAB14
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input	[Complex:R-HSA-8876596] GGC-RAB14:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8876664] Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes [LiteratureReference:8876633] A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes [LiteratureReference:8876662] Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells [LiteratureReference:8876675] Rab14 regulation of claudin-2 trafficking modulates epithelial permeability and lumen morphogenesis [LiteratureReference:3827964] ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation [LiteratureReference:8876634] ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling [LiteratureReference:8876639] ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles [LiteratureReference:8876657] Junctional adhesion molecule-C is a soluble mediator of angiogenesis [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	DENND6A,B exchange GTP for GDP on RAB14
orthologousEvent	[Reaction:R-DDI-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Dictyostelium discoideum [Reaction:R-CEL-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Caenorhabditis elegans [Reaction:R-DME-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Drosophila melanogaster [Reaction:R-GGA-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Gallus gallus [Reaction:R-DRE-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Danio rerio [Reaction:R-BTA-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Bos taurus [Reaction:R-RNO-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Rattus norvegicus [Reaction:R-MMU-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Mus musculus
output	[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-8876595] GGC-RAB14:GTP [recycling endosome membrane]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8876616
summation	[Summation:8876659] RAB14 is involved in the trafficking of GLUT4 to the plasma ...

Referrals

(hasEvent)

[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs

Cite Us!