Reactome | MON1:CCZ1 exchanges GTP for GDP on RAB7

Schema > Reaction > Entries

MON1:CCZ1 exchanges GTP for GDP on RAB7 Show undefined attributes

authored	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
catalystActivity	[CatalystActivity:8877445] guanyl-nucleotide exchange factor activity of MON1:CCZ1 [cytosol]
category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:70101] cytosol
created	[InstanceEdit:8877452] Rothfels, Karen, 2016-06-22
dbId	8877451
displayName	MON1:CCZ1 exchanges GTP for GDP on RAB7
edited	[InstanceEdit:8878001] Rothfels, Karen, 2016-06-28
eventOf	[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input	[Complex:R-HSA-8877449] GGC-RAB7:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8871102] Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments [LiteratureReference:8877540] Rab 7: an important regulator of late endocytic membrane traffic [LiteratureReference:8877590] Role of the small GTPase Rab7 in the late endocytic pathway [LiteratureReference:8877534] Membrane dynamics and fusion at late endosomes and vacuoles--Rab regulation, multisubunit tethering complexes and SNAREs [LiteratureReference:8877550] Tethering complexes in the endocytic pathway: CORVET and HOPS [LiteratureReference:8877563] The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7 [LiteratureReference:8877519] BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor [LiteratureReference:8877528] Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells [LiteratureReference:8877555] The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways [LiteratureReference:8877523] Identification of the switch in early-to-late endosome transition [LiteratureReference:8877520] CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion [LiteratureReference:8877568] Rab7: role of its protein interaction cascades in endo-lysosomal traffic [LiteratureReference:2028856] Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP [LiteratureReference:8877548] Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes [LiteratureReference:8877586] Rab7 is required for the normal progression of the autophagic pathway in mammalian cells [LiteratureReference:8877577] Maturation of autophagosomes and endosomes: a key role for Rab7 [LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	MON1:CCZ1 exchanges GTP for GDP on RAB7
orthologousEvent	[Reaction:R-PFA-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Plasmodium falciparum [Reaction:R-SCE-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Saccharomyces cerevisiae [Reaction:R-DDI-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Dictyostelium discoideum [Reaction:R-CEL-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Caenorhabditis elegans [Reaction:R-DME-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Drosophila melanogaster [Reaction:R-GGA-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Gallus gallus [Reaction:R-SSC-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Sus scrofa [Reaction:R-BTA-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Bos taurus [Reaction:R-CFA-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Canis familiaris [Reaction:R-RNO-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Rattus norvegicus [Reaction:R-MMU-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Mus musculus
output	[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-8877453] GGC-RAB7:GTP [lysosomal membrane]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8877451
summation	[Summation:8877570] RAB7 acts downstream of RAB5 in a RAB cascade that regulates...

Referrals

(hasEvent)

[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs

Cite Us!