RAS GEFs promote RAS nucleotide exchange

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The human genome is predicted to encode 27 RAS guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP on membrane-associated RAS in response to RAS-MAPK pathway activation by growth factors, hormones, cytokines and other stimuli (reviewed in Cherfils and Zeghouf, 2013; Cargnello and Roux, 2011). Nucleotide exchange stimulates a conformational change in RAS to facilitate its interaction with RAF, ultimately promoting the phosphorylation of downstream effectors MAPK3 and MAPK1 (also known as ERK1 and ERK2) (reviewed in Cseh et al, 2014; Vigil et al, 2010).
Literature References
PubMed ID Title Journal Year
21372320 Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

Roux, PP, Cargnello, M

Microbiol. Mol. Biol. Rev. 2011
24937142 "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway

Baccarini, M, Cseh, B, Doma, E

FEBS Lett. 2014
21102635 Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Der, CJ, Vigil, D, Rossman, KL, Cherfils, J

Nat. Rev. Cancer 2010
23303910 Regulation of small GTPases by GEFs, GAPs, and GDIs

Zeghouf, M, Cherfils, J

Physiol. Rev. 2013
Catalyst Activity

guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane]

Orthologous Events
Cite Us!