Reactome | RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated

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RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated Show undefined attributes

authored	[InstanceEdit:1168647] May, B, 2011-01-03
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1168378] May, B, 2010-12-18
dbId	1168374
displayName	RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated
edited	[InstanceEdit:1168377] May, B, 2010-12-09
eventOf	[Pathway:R-HSA-1169092] Activation of RAS in B cells - Homo sapiens
followingEvent	[Reaction:R-HSA-1168636] p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP - Homo sapiens [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-1169494] Rasgrp1 and Rasgrp3 are recruited to the membrane and phosphorylated - Mus musculus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-114519] DAG [plasma membrane] [DefinedSet:R-HSA-1169462] RASGRP1,3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1168355] Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells [LiteratureReference:1169555] Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3 [LiteratureReference:1168353] Phorbol esters modulate the Ras exchange factor RasGRP3 [LiteratureReference:1169518] RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling [LiteratureReference:1169597] Protein kinase C-theta (PKCtheta) distribution analysis in hematopoietic cells: proliferating T cells exhibit high proportions of PKCtheta in the particulate fraction
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1168369] p-RASGRP1,3:DAG [plasma membrane]
precedingEvent	[Reaction:R-HSA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1168374
summation	[Summation:1169501] RasGRP1 and RasGRP3 translocate to the plasma membrane where...

Referrals

(hasEvent)	[Pathway:R-HSA-1169092] Activation of RAS in B cells
(precedingEvent)	[Reaction:R-HSA-1168636] p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[BlackBoxEvent:R-MMU-1169494] Rasgrp1 and Rasgrp3 are recruited to the membrane and phosphorylated

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