Reactome | Recruitment of GRB2:SOS to p-5Y-LAT

Schema > Reaction > Entries

Recruitment of GRB2:SOS to p-5Y-LAT Show undefined attributes

authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2396559] Garapati, P V, 2012-07-09
dbId	2396599
displayName	Recruitment of GRB2:SOS to p-5Y-LAT
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
eventOf	[Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens [Pathway:R-HSA-2424491] DAP12 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-2424477] SOS mediated nucleotide exchange of RAS (SHC) - Homo sapiens [Reaction:R-HSA-2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT - Homo sapiens [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2396597] p-5Y-LAT-2 [plasma membrane] [Complex:R-HSA-2685672] p-SHC1:GRB2:SOS [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202315] Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. [LiteratureReference:2685288] Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Recruitment of GRB2:SOS to p-5Y-LAT
orthologousEvent	[Reaction:R-SSC-2396599] Recruitment of GRB2:SOS to p-5Y-LAT - Sus scrofa [Reaction:R-BTA-2396599] Recruitment of GRB2:SOS to p-5Y-LAT - Bos taurus [Reaction:R-CFA-2396599] Recruitment of GRB2:SOS to p-5Y-LAT - Canis familiaris [Reaction:R-RNO-2396599] Recruitment of GRB2:SOS to p-5Y-LAT - Rattus norvegicus [Reaction:R-MMU-2396599] Recruitment of GRB2:SOS to p-5Y-LAT - Mus musculus
output	[Complex:R-HSA-2424468] p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2730844] Interaction of GRB2:SOS complex with p-SHC1 - Homo sapiens [Reaction:R-HSA-2395801] Phosphorylation of LAT by p-SYK - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2396599
summation	[Summation:2396536] GRB2 is an adapter protein that contains a central SH2 domai...
updateTrackers	[UpdateTracker:9787641] Update Tracker - [Reaction:2396599] Recruitment of GRB2:SOS to p-5Y-LAT - v44:[addLiteratureReference, add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9787641] Update Tracker - [Reaction:2396599] Recruitment of GRB2:SOS to p-5Y-LAT - v44:[addLiteratureReference, add_removeInput]
(hasEvent)	[Pathway:R-HSA-2424491] DAP12 signaling [Pathway:R-HSA-2871796] FCERI mediated MAPK activation
(precedingEvent)	[Reaction:R-HSA-2424477] SOS mediated nucleotide exchange of RAS (SHC) [Reaction:R-HSA-2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange