Reactome | RAS GEFs promote RAS nucleotide exchange

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RAS GEFs promote RAS nucleotide exchange Show undefined attributes

catalystActivity	[CatalystActivity:10292955] guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10292957
displayName	RAS GEFs promote RAS nucleotide exchange
eventOf	[Pathway:R-CFA-5673001] RAF/MAP kinase cascade - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9660557] RAS:GTP binds RAL GDS proteins - Canis familiaris [Reaction:R-CFA-9658253] RAS:GTP binds PI3K - Canis familiaris
inferredFrom	[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-CFA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RAS GEFs promote RAS nucleotide exchange
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-CFA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-CFA-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1 - Canis familiaris [Reaction:R-CFA-5654597] Activated FGFR1:p-SHC1 binds GRB2:SOS1 - Canis familiaris [Reaction:R-CFA-5654615] Activated FGFR2:pFRS binds GRB2:SOS1 - Canis familiaris [Reaction:R-CFA-5654406] Activated FGFR2:p-SHC1 binds GRB2:SOS1 - Canis familiaris [Reaction:R-CFA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Canis familiaris [Reaction:R-CFA-5654646] Activated FGFR3:p-SHC1 binds GRB2:SOS1 - Canis familiaris [Reaction:R-CFA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Canis familiaris [Reaction:R-CFA-5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1 - Canis familiaris [Reaction:R-CFA-392053] SOS binds Grb2 bound to pFAK:NCAM1 - Canis familiaris [Reaction:R-CFA-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers - Canis familiaris [Reaction:R-CFA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Canis familiaris [Reaction:R-CFA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Canis familiaris [Reaction:R-CFA-74746] GRB2-1:SOS1 binds p-Y427-SHC1 - Canis familiaris [Reaction:R-CFA-2396599] Recruitment of GRB2:SOS to p-5Y-LAT - Canis familiaris [Reaction:R-CFA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Canis familiaris [Reaction:R-CFA-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Canis familiaris [Reaction:R-CFA-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Canis familiaris [Reaction:R-CFA-186826] GRB2:SOS1 complex binds to the active receptor - Canis familiaris [Reaction:R-CFA-210974] Interaction of SOS-1 to Tie2 bound Grb2 - Canis familiaris [Reaction:R-CFA-205286] GRB2:SOS interacts with p-KIT - Canis familiaris [Reaction:R-CFA-453111] Phosphorylated SHC recruits GRB2:SOS1 - Canis familiaris [Reaction:R-CFA-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Canis familiaris [Reaction:R-CFA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Canis familiaris [Reaction:R-CFA-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 - Canis familiaris [Reaction:R-CFA-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET - Canis familiaris [Reaction:R-CFA-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5672965
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5673001] RAF/MAP kinase cascade
(precedingEvent)	[Reaction:R-CFA-9660557] RAS:GTP binds RAL GDS proteins [Reaction:R-CFA-9658253] RAS:GTP binds PI3K
(inferredTo)	[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange

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