Reactome | Degradation of the extracellular matrix

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Degradation of the extracellular matrix Show undefined attributes

authored	[InstanceEdit:1592294] Jupe, S, 2011-09-09
created	[InstanceEdit:1474220] Jupe, S, 2011-08-05
dbId	1474228
displayName	Degradation of the extracellular matrix
doi	10.3180/REACT_118572.5
edited	[InstanceEdit:2129374] Jupe, S, 2012-02-21
eventOf	[TopLevelPathway:R-HSA-1474244] Extracellular matrix organization - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:261789] extracellular matrix disassembly
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases - Homo sapiens [Pathway:R-HSA-1442490] Collagen degradation - Homo sapiens [Reaction:R-HSA-1566962] Elastin degradation by elastin-degrading extracellular proteinases - Homo sapiens [BlackBoxEvent:R-HSA-2514790] Elastin degradation by MMP14 - Homo sapiens [Reaction:R-HSA-2485148] Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 - Homo sapiens [Reaction:R-HSA-2514772] Fibrillin-1 degradation by MMP3, CTSK, CTSL2 - Homo sapiens [Reaction:R-HSA-2514831] Fibrillin-1 degradation by MMP14 - Homo sapiens [Reaction:R-HSA-2514823] Fibrillin-1 degradation by ELANE - Homo sapiens [Reaction:R-HSA-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Homo sapiens [Reaction:R-HSA-2533944] Fibronectin degradation by MMP10 - Homo sapiens [Reaction:R-HSA-2533950] Fibronectin degradation by MMP14 - Homo sapiens [Reaction:R-HSA-3785684] Fibronectin degradation by CTSG - Homo sapiens [Reaction:R-HSA-3788061] Fibronectin degradation by ADAM8 - Homo sapiens [Reaction:R-HSA-1566979] Laminin-332 degradation by laminin-322 degrading extracellular proteinases - Homo sapiens [Reaction:R-HSA-3791155] Laminin-322 degradation by MMP14 - Homo sapiens [Reaction:R-HSA-2533874] Laminin-511 degradation by MMP14 - Homo sapiens [Reaction:R-HSA-1592270] NID1 degradation by MMP1, 9, 12, ELANE - Homo sapiens [Reaction:R-HSA-2533970] NID1 degradation by MMP3, 7 - Homo sapiens [Reaction:R-HSA-2533965] NID1 degradation by MMP14, MMP15 - Homo sapiens [Reaction:R-HSA-3791319] NID1 degradation by MMP19 - Homo sapiens [Reaction:R-HSA-1592310] Aggrecan degradation by ADAMTSs - Homo sapiens [Reaction:R-HSA-3791295] Aggrecan degradation by MMP1,2,3,7,9,12,13 - Homo sapiens [Reaction:R-HSA-8855825] HTRA1 hydrolyzes ACAN (Aggrecan) - Homo sapiens [Reaction:R-HSA-3788075] Brevican degradation by ADAMTS4, ADAMTS5 - Homo sapiens [Reaction:R-HSA-3791149] Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 - Homo sapiens [Reaction:R-HSA-1592314] HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) - Homo sapiens [Reaction:R-HSA-2534160] HSPG2 (perlecan) degradation by MMP13, CTSS - Homo sapiens [Reaction:R-HSA-2534240] HSPG2 (perlecan) degradation by MMP14, MMP15 - Homo sapiens [Reaction:R-HSA-3814820] HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 - Homo sapiens [Reaction:R-HSA-2534248] DCN (decorin) degradation by MMP2, MMP3, MMP7 - Homo sapiens [Reaction:R-HSA-3828025] DCN (decorin) degradation by MMP14 - Homo sapiens [Reaction:R-HSA-1454843] E-cadherin degradation by MMP3, MMP7 and plasmin - Homo sapiens [Reaction:R-HSA-3827958] E-cadherin degradation by MMP9, KLK7 - Homo sapiens [Reaction:R-HSA-4224014] E-cadherin degradation by ADAM10, ADAM15 - Homo sapiens [Reaction:R-HSA-2534206] E-cadherin degradation by PS1:NCSTN (Gamma-secretase) - Homo sapiens [Reaction:R-HSA-2534260] E-cadherin degradation by caspase-3 and calpain-1 - Homo sapiens [Reaction:R-HSA-1454781] MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin - Homo sapiens [Reaction:R-HSA-1454791] MMP2, MMP7, MMP9 bind CD44 - Homo sapiens [Reaction:R-HSA-375135] Basigin binds Matrix metalloproteinase-1 - Homo sapiens [Reaction:R-HSA-4086205] OPN (osteopontin) degradation by MMP3, MMP7 - Homo sapiens [Reaction:R-HSA-8848658] CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins - Homo sapiens [Reaction:R-HSA-8940554] MMP2 cleaves OPTC - Homo sapiens [Reaction:R-HSA-8940561] MMP7 cleaves OPTC - Homo sapiens [Reaction:R-HSA-8942302] MMP13 cleaves OPTC - Homo sapiens [Reaction:R-HSA-8943959] MMP2, MMP9 cleave SCUBE3 - Homo sapiens [Polymerisation:R-HSA-8943987] SCUBE1, SCUBE3 oligomerize - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-03-16
literatureReference	[LiteratureReference:2060902] Extracellular matrix degradation and remodeling in development and disease
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Degradation of the extracellular matrix
orthologousEvent	[Pathway:R-PFA-1474228] Degradation of the extracellular matrix - Plasmodium falciparum [Pathway:R-SPO-1474228] Degradation of the extracellular matrix - Schizosaccharomyces pombe [Pathway:R-DDI-1474228] Degradation of the extracellular matrix - Dictyostelium discoideum [Pathway:R-CEL-1474228] Degradation of the extracellular matrix - Caenorhabditis elegans [Pathway:R-DME-1474228] Degradation of the extracellular matrix - Drosophila melanogaster [Pathway:R-GGA-1474228] Degradation of the extracellular matrix - Gallus gallus [Pathway:R-XTR-1474228] Degradation of the extracellular matrix - Xenopus tropicalis [Pathway:R-DRE-1474228] Degradation of the extracellular matrix - Danio rerio [Pathway:R-SSC-1474228] Degradation of the extracellular matrix - Sus scrofa [Pathway:R-BTA-1474228] Degradation of the extracellular matrix - Bos taurus [Pathway:R-CFA-1474228] Degradation of the extracellular matrix - Canis familiaris [Pathway:R-RNO-1474228] Degradation of the extracellular matrix - Rattus norvegicus [Pathway:R-MMU-1474228] Degradation of the extracellular matrix - Mus musculus
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2157530] D'Eustachio, P, 2012-02-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1474228
summation	[Summation:1442485] Matrix metalloproteinases (MMPs), previously referred to as ...
updateTrackers	[UpdateTracker:9783640] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v56:[addHasEvent] [UpdateTracker:9863967] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v88:[updateContainedRLE] [UpdateTracker:9777091] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v72:[updateIndirectRLE] [UpdateTracker:9788712] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v41:[updateIndirectRLE] [UpdateTracker:9784320] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v54:[updateContainedPathway] [UpdateTracker:9787269] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v46:[addHasEvent] [UpdateTracker:9782536] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v59:[addHasEvent, updateIndirectRLE] [UpdateTracker:9788218] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v43:[addHasEvent, updateIndirectRLE] [UpdateTracker:9781903] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v60:[addHasEvent] [UpdateTracker:9777748] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v69:[updateIndirectRLE] [UpdateTracker:9783259] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v57:[add_removeHasEvent, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9788433] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v42:[updateContainedPathway]

Referrals

(hasEvent)

[TopLevelPathway:R-HSA-1474244] Extracellular matrix organization

(updatedInstance)

[UpdateTracker:9783640] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v56:[addHasEvent]
[UpdateTracker:9863967] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v88:[updateContainedRLE]
[UpdateTracker:9777091] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v72:[updateIndirectRLE]
[UpdateTracker:9788712] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v41:[updateIndirectRLE]
[UpdateTracker:9784320] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v54:[updateContainedPathway]
[UpdateTracker:9787269] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v46:[addHasEvent]
[UpdateTracker:9782536] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v59:[addHasEvent, updateIndirectRLE]
[UpdateTracker:9788218] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v43:[addHasEvent, updateIndirectRLE]
[UpdateTracker:9781903] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v60:[addHasEvent]
[UpdateTracker:9777748] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v69:[updateIndirectRLE]
[UpdateTracker:9783259] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v57:[add_removeHasEvent, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9788433] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v42:[updateContainedPathway]

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