Reactome | Fibrillin-1 degradation by ELANE

Schema > Reaction > Entries

authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:2482187] serine-type endopeptidase activity of ELANE [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:2514825] Jupe, S, 2012-10-10
dbId	2514823
displayName	Fibrillin-1 degradation by ELANE
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
eventOf	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
inferredFrom	[Reaction:R-NUL-2514835] Degradation of fibrilin-1 by Elane - Bos taurus
input	[Polymer:R-HSA-2159874] Fibrillin-1 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Fibrillin-1 degradation by ELANE Fibrillin-1 degradation by neutrophil elastase
output	[Polymer:R-HSA-2514812] Cleaved fibrillin-1 [extracellular region]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2514823
summation	[Summation:2514819] Fibrillin-1, the major structural component of microfibrils ...

(hasEvent)	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix
(inferredTo)	[Reaction:R-NUL-2514835] Degradation of fibrilin-1 by Elane

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