Reactome | E-cadherin degradation by ADAM10, ADAM15

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E-cadherin degradation by ADAM10, ADAM15 Show undefined attributes

authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:4224012] metalloendopeptidase activity of ADAM10, ADAM15 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:4224011] Jupe, S, 2013-08-16
dbId	4224014
displayName	E-cadherin degradation by ADAM10, ADAM15
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
eventOf	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
input	[Complex:R-HSA-2534182] CDH1(155-882):Ca2+ dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3827964] ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation [LiteratureReference:3828016] The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	E-cadherin degradation by ADAM10, ADAM15
orthologousEvent	[Reaction:R-GGA-4224014] E-cadherin degradation by ADAM10, ADAM15 - Gallus gallus [Reaction:R-XTR-4224014] E-cadherin degradation by ADAM10, ADAM15 - Xenopus tropicalis [Reaction:R-DRE-4224014] E-cadherin degradation by ADAM10, ADAM15 - Danio rerio [Reaction:R-SSC-4224014] E-cadherin degradation by ADAM10, ADAM15 - Sus scrofa [Reaction:R-BTA-4224014] E-cadherin degradation by ADAM10, ADAM15 - Bos taurus [Reaction:R-CFA-4224014] E-cadherin degradation by ADAM10, ADAM15 - Canis familiaris [Reaction:R-RNO-4224014] E-cadherin degradation by ADAM10, ADAM15 - Rattus norvegicus [Reaction:R-MMU-4224014] E-cadherin degradation by ADAM10, ADAM15 - Mus musculus
output	[Complex:R-HSA-2534301] E-cadherin strand dimer fragment 155-700 [plasma membrane] [Complex:R-HSA-2534305] E-cadherin strand dimer fragment 701-882 [plasma membrane]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4224014
summation	[Summation:4224010] E-cadherin (CDH1) localizes to the lateral membrane of diffe...

Referrals

(hasEvent)

[Pathway:R-HSA-1474228] Degradation of the extracellular matrix