Reactome | Brevican degradation by MMP1, 2, 3, 7,8,10,13,19

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Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 Show undefined attributes

authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:3791136] metalloendopeptidase activity of MMP1, 2, 3, 7,8,10,13,19 [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:3791165] Jupe, S, 2013-07-05
dbId	3791149
displayName	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
eventOf	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
input	[DefinedSet:R-HSA-2681671] Brevican [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3791169] Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites [LiteratureReference:3787938] Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Brevican degradation by MMP1, 2, 3, 7,8,10,13,19
orthologousEvent	[Reaction:R-GGA-3791149] Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 - Gallus gallus [Reaction:R-XTR-3791149] Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 - Xenopus tropicalis [Reaction:R-DRE-3791149] Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 - Danio rerio [Reaction:R-SSC-3791149] Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 - Sus scrofa [Reaction:R-BTA-3791149] Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 - Bos taurus [Reaction:R-CFA-3791149] Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 - Canis familiaris [Reaction:R-RNO-3791149] Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 - Rattus norvegicus [Reaction:R-MMU-3791149] Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 - Mus musculus
output	[DefinedSet:R-HSA-3791183] Brevican(23-360) [extracellular region] [DefinedSet:R-HSA-3791187] Brevican(361-911) [extracellular region]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3791149
summation	[Summation:3791129] Brevican, a member of the lectican family, is one of the mos...

Referrals

(hasEvent)

[Pathway:R-HSA-1474228] Degradation of the extracellular matrix