Reactome | Fibronectin degradation by MMP14

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Fibronectin degradation by MMP14 Show undefined attributes

authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:9863899] metalloendopeptidase activity of MMP14 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2533918] Jupe, S, 2012-10-22
dbId	2533950
displayName	Fibronectin degradation by MMP14
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
eventOf	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
input	[Polymer:R-HSA-2327729] Fibronectin matrix [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2485117] MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin [LiteratureReference:9863898] Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly to promote cell motility
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Fibronectin degradation by MMP14
orthologousEvent	[Reaction:R-CEL-2533950] Fibronectin degradation by MMP14 - Caenorhabditis elegans [Reaction:R-XTR-2533950] Fibronectin degradation by MMP14 - Xenopus tropicalis [Reaction:R-DRE-2533950] Fibronectin degradation by MMP14 - Danio rerio [Reaction:R-SSC-2533950] Fibronectin degradation by MMP14 - Sus scrofa [Reaction:R-BTA-2533950] Fibronectin degradation by MMP14 - Bos taurus [Reaction:R-CFA-2533950] Fibronectin degradation by MMP14 - Canis familiaris [Reaction:R-RNO-2533950] Fibronectin degradation by MMP14 - Rattus norvegicus [Reaction:R-MMU-2533950] Fibronectin degradation by MMP14 - Mus musculus
output	[Polymer:R-HSA-2533900] Cleaved fibronectin matrix [extracellular region]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2533950
summation	[Summation:2533849] MMP14 (MT1-MMP) can degrade fibronectin (Shi & Sottile 2011;...
updateTrackers	[UpdateTracker:9783032] Update Tracker - [Reaction:2533950] Fibronectin degradation by MMP14, TMPRSS6 - v57:[addLiteratureReference, modifyText] [UpdateTracker:9864114] Update Tracker - [Reaction:2533950] Fibronectin degradation by MMP14 - v88:[add_removeCatalystActivity, add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783032] Update Tracker - [Reaction:2533950] Fibronectin degradation by MMP14, TMPRSS6 - v57:[addLiteratureReference, modifyText] [UpdateTracker:9864114] Update Tracker - [Reaction:2533950] Fibronectin degradation by MMP14 - v88:[add_removeCatalystActivity, add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix