Reactome | Degradation of the extracellular matrix

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Degradation of the extracellular matrix Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100015
displayName	Degradation of the extracellular matrix
eventOf	[TopLevelPathway:R-MMU-1474244] Extracellular matrix organization - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:261789] extracellular matrix disassembly
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-MMU-1592389] Activation of Matrix Metalloproteinases - Mus musculus [Pathway:R-MMU-1442490] Collagen degradation - Mus musculus [Reaction:R-MMU-1566962] Elastin degradation by elastin-degrading extracellular proteinases - Mus musculus [BlackBoxEvent:R-MMU-2514790] Elastin degradation by MMP14 - Mus musculus [Reaction:R-MMU-2485148] Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 - Mus musculus [Reaction:R-MMU-2514772] Fibrillin-1 degradation by MMP3, CTSK, CTSL2 - Mus musculus [Reaction:R-MMU-2514831] Fibrillin-1 degradation by MMP14 - Mus musculus [Reaction:R-MMU-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Mus musculus [Reaction:R-MMU-2533950] Fibronectin degradation by MMP14 - Mus musculus [Reaction:R-MMU-3785684] Fibronectin degradation by CTSG - Mus musculus [Reaction:R-MMU-3788061] Fibronectin degradation by ADAM8 - Mus musculus [Reaction:R-MMU-3791319] NID1 degradation by MMP19 - Mus musculus [Reaction:R-MMU-8855825] HTRA1 hydrolyzes ACAN (Aggrecan) - Mus musculus [Reaction:R-MMU-3788075] Brevican degradation by ADAMTS4, ADAMTS5 - Mus musculus [Reaction:R-MMU-3791149] Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 - Mus musculus [Reaction:R-MMU-2534248] DCN (decorin) degradation by MMP2, MMP3, MMP7 - Mus musculus [Reaction:R-MMU-3828025] DCN (decorin) degradation by MMP14 - Mus musculus [Reaction:R-MMU-3827958] E-cadherin degradation by MMP9, KLK7 - Mus musculus [Reaction:R-MMU-4224014] E-cadherin degradation by ADAM10, ADAM15 - Mus musculus [Reaction:R-MMU-1454781] MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin - Mus musculus [Reaction:R-MMU-1454791] MMP2, MMP7, MMP9 bind CD44 - Mus musculus [Reaction:R-MMU-375135] Basigin binds Matrix metalloproteinase-1 - Mus musculus [Reaction:R-MMU-4086205] OPN (osteopontin) degradation by MMP3, MMP7 - Mus musculus [Reaction:R-MMU-8848658] CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins - Mus musculus [Reaction:R-MMU-8940554] MMP2 cleaves OPTC - Mus musculus [Reaction:R-MMU-8940561] MMP7 cleaves OPTC - Mus musculus [Reaction:R-MMU-8942302] MMP13 cleaves OPTC - Mus musculus [Reaction:R-MMU-8943959] MMP2, MMP9 cleave SCUBE3 - Mus musculus [Polymerisation:R-MMU-8943987] SCUBE1, SCUBE3 oligomerize - Mus musculus
inferredFrom	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Degradation of the extracellular matrix
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-1474228
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-MMU-1474244] Extracellular matrix organization
(inferredTo)	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix

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