Reactome | HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1

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HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 Show undefined attributes

authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:3828026] serine-type endopeptidase activity of BMP1, TLL1, TLL2, Cathepsin L1 [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:3814823] Jupe, S, 2013-07-08
dbId	3814820
displayName	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
eventOf	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1011570] HSPG2(22-4391) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3828012] BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan [LiteratureReference:3828007] Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1
orthologousEvent	[Reaction:R-CEL-3814820] HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 - Caenorhabditis elegans [Reaction:R-DME-3814820] HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 - Drosophila melanogaster
output	[EntityWithAccessionedSequence:R-HSA-3827968] HSPG2(22-4196) [extracellular region] [EntityWithAccessionedSequence:R-HSA-3827980] HSPG2(4197-4391) [extracellular region]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3814820
summation	[Summation:3814824] Endorepellin is the 85-kDa C-terminal domain V of HSPG2 (per...

Referrals

(hasEvent)

[Pathway:R-HSA-1474228] Degradation of the extracellular matrix

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