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Schema
>
Reaction
>
Entries
HTRA1 hydrolyzes ACAN (Aggrecan)
Show undefined attributes
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authored
[InstanceEdit:8855824] D'Eustachio, Peter, 2016-02-05
catalystActivity
[CatalystActivity:8855862] serine-type endopeptidase activity of HTRA1 trimer [extracellular region]
catalystActivityReference
[CatalystActivityReference:9643184] serine-type endopeptidase activity of HTRA1 trimer [extracellular region] Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage
category
transition
compartment
[Compartment:984] extracellular region
created
[InstanceEdit:8855824] D'Eustachio, Peter, 2016-02-05
dbId
8855825
displayName
HTRA1 hydrolyzes ACAN (Aggrecan)
edited
[InstanceEdit:8855824] D'Eustachio, Peter, 2016-02-05
eventOf
[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
input
[DefinedSet:R-HSA-2318622] Aggrecan [extracellular region]
[SimpleEntity:R-ALL-109276] H2O [extracellular region]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8855861] Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo
[LiteratureReference:8855826] Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage
[LiteratureReference:8855821] HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins
[LiteratureReference:8855848] Substrate-induced remodeling of the active site regulates human HTRA1 activity
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
HTRA1 hydrolyzes ACAN (Aggrecan)
orthologousEvent
[Reaction:R-GGA-8855825] HTRA1 hydrolyzes ACAN (Aggrecan) - Gallus gallus
[Reaction:R-DRE-8855825] HTRA1 hydrolyzes ACAN (Aggrecan) - Danio rerio
[Reaction:R-SSC-8855825] HTRA1 hydrolyzes ACAN (Aggrecan) - Sus scrofa
[Reaction:R-BTA-8855825] HTRA1 hydrolyzes ACAN (Aggrecan) - Bos taurus
[Reaction:R-CFA-8855825] HTRA1 hydrolyzes ACAN (Aggrecan) - Canis familiaris
[Reaction:R-RNO-8855825] HTRA1 hydrolyzes ACAN (Aggrecan) - Rattus norvegicus
[Reaction:R-MMU-8855825] HTRA1 hydrolyzes ACAN (Aggrecan) - Mus musculus
output
[DefinedSet:R-HSA-8855843] ACAN(17-375) [extracellular region]
[DefinedSet:R-HSA-8855819] ACAN(376-2415) [extracellular region]
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8856053] Jupe, Steve, 2016-02-08
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8855825
summation
[Summation:8855832] Extracellular HTRA1 (High-temperature requirement A serine p...
Referrals
(hasEvent)
[Pathway:R-HSA-1474228] Degradation of the extracellular matrix
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