Reactome | MMP13 cleaves OPTC

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MMP13 cleaves OPTC Show undefined attributes

authored	[InstanceEdit:8940521] Jupe, Steve, 2016-09-27
catalystActivity	[CatalystActivity:8942298] metalloendopeptidase activity of MMP13 [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:8942313] Jupe, Steve, 2016-10-12
dbId	8942302
displayName	MMP13 cleaves OPTC
edited	[InstanceEdit:8941325] Jupe, Steve, 2016-09-30
eventOf	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8940538] OPTC [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8940527] Characterization of opticin digestion by proteases involved in osteoarthritis development
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MMP13 cleaves OPTC
orthologousEvent	[Reaction:R-GGA-8942302] MMP13 cleaves OPTC - Gallus gallus [Reaction:R-XTR-8942302] MMP13 cleaves OPTC - Xenopus tropicalis [Reaction:R-SSC-8942302] MMP13 cleaves OPTC - Sus scrofa [Reaction:R-BTA-8942302] MMP13 cleaves OPTC - Bos taurus [Reaction:R-CFA-8942302] MMP13 cleaves OPTC - Canis familiaris [Reaction:R-RNO-8942302] MMP13 cleaves OPTC - Rattus norvegicus [Reaction:R-MMU-8942302] MMP13 cleaves OPTC - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8942317] OPTC(115-332) [extracellular region] [EntityWithAccessionedSequence:R-HSA-8942311] OPTC(20-114) [extracellular region]
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942310] Ricard-Blum, Sylvie, 2016-10-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8942302
summation	[Summation:8942312] Opticin (OPTC) is a a member of the small leucine-rich repea...

Referrals

(hasEvent)

[Pathway:R-HSA-1474228] Degradation of the extracellular matrix

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