Reactome | Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS

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Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS Show undefined attributes

authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:2533916] serine-type endopeptidase activity of MMP1, 3, 7, 12, 13, 19, CTSS [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1566968] Jupe, S, 2011-09-06
dbId	1566981
displayName	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
eventOf	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
input	[Polymer:R-HSA-2327729] Fibronectin matrix [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1566943] Release of biological activities from quiescent fibronectin by a conformational change and limited proteolysis by matrix metalloproteinases [LiteratureReference:1566947] Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase [LiteratureReference:1564199] The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction [LiteratureReference:2514832] Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation [LiteratureReference:2537521] Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS
orthologousEvent	[Reaction:R-DDI-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Dictyostelium discoideum [Reaction:R-CEL-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Caenorhabditis elegans [Reaction:R-GGA-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Gallus gallus [Reaction:R-XTR-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Xenopus tropicalis [Reaction:R-DRE-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Danio rerio [Reaction:R-SSC-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Sus scrofa [Reaction:R-BTA-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Bos taurus [Reaction:R-CFA-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Canis familiaris [Reaction:R-RNO-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Rattus norvegicus [Reaction:R-MMU-1566981] Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS - Mus musculus
output	[Polymer:R-HSA-2533900] Cleaved fibronectin matrix [extracellular region]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1566981
summation	[Summation:1566944] MMP1 can degrade fibronectin (Fukai et al. 1995), as can MMP...

Referrals

(hasEvent)

[Pathway:R-HSA-1474228] Degradation of the extracellular matrix

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