Reactome | E-cadherin degradation by caspase-3 and calpain-1

Schema > Reaction > Entries

authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:2534299] serine-type endopeptidase activity of Active caspase-3 heterotetramer, calpain-1 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2534268] Jupe, S, 2012-10-24
dbId	2534260
displayName	E-cadherin degradation by caspase-3 and calpain-1
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
eventOf	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
inferredFrom	[Reaction:R-NUL-2534247] E-cadherin strand dimer degradation by Casp3 - Homo sapiens
input	[Complex:R-HSA-2534182] CDH1(155-882):Ca2+ dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E-cadherin degradation by caspase-3 and calpain-1
output	[Complex:R-HSA-3827963] E-cadherin strand dimer fragment 155-750 [plasma membrane] [Complex:R-HSA-3828004] E-cadherin strand dimer fragment 751-882 [plasma membrane]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2534260
summation	[Summation:3827971] E-cadherin (CDH1) localizes to the lateral membrane of diffe...

(hasEvent)	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix
(inferredTo)	[Reaction:R-NUL-2534247] E-cadherin strand dimer degradation by Casp3

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