Reactome | HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)

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HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) Show undefined attributes

authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:2534252] serine-type endopeptidase activity of MMP3, plasmin, (MMP12) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1592294] Jupe, S, 2011-09-09
dbId	1592314
displayName	HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
eventOf	[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1011570] HSPG2(22-4391) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1592399] The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)
orthologousEvent	[Reaction:R-CEL-1592314] HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) - Caenorhabditis elegans [Reaction:R-DME-1592314] HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) - Drosophila melanogaster
output	[EntityWithAccessionedSequence:R-HSA-2534251] HSPG2(22-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2534246] HSPG2(?-4391) [extracellular region]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1592314
summation	[Summation:1592408] HSPG2 protein (perlecan) consists of a core protein of molec...

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(hasEvent)

[Pathway:R-HSA-1474228] Degradation of the extracellular matrix

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