Reactome | GRB2 is indirectly recruited to p-KIT through SHP2

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GRB2 is indirectly recruited to p-KIT through SHP2 Show undefined attributes

authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1433498] Garapati, P V, 2011-07-11
dbId	1433428
displayName	GRB2 is indirectly recruited to p-KIT through SHP2
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
eventOf	[Pathway:R-HSA-1433557] Signaling by SCF-KIT - Homo sapiens
followingEvent	[Reaction:R-HSA-205234] Indirect recruitment of GAB2 to p-KIT - Homo sapiens [Reaction:R-HSA-1433471] Activation of RAS by p-KIT bound SOS1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol] [Complex:R-HSA-1433530] p-SHP2:p-KIT complex [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1433319] Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction [LiteratureReference:205299] The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells [LiteratureReference:1433436] ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	GRB2 is indirectly recruited to p-KIT through SHP2
orthologousEvent	[Reaction:R-GGA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Gallus gallus [Reaction:R-XTR-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Xenopus tropicalis [Reaction:R-DRE-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Danio rerio [Reaction:R-SSC-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Sus scrofa [Reaction:R-BTA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Bos taurus [Reaction:R-CFA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Canis familiaris [Reaction:R-RNO-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Rattus norvegicus [Reaction:R-MMU-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Mus musculus
output	[Complex:R-HSA-1433549] GRB2:p-SHP2:p-KIT complex [plasma membrane]
precedingEvent	[Reaction:R-HSA-1433488] Phosphorylation of SHP2 by SFKs - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1433428
summation	[Summation:1433455] GRB2 can be recruited indirectly to KIT through SHP2 (Tauchi...

Referrals

(hasEvent)	[Pathway:R-HSA-1433557] Signaling by SCF-KIT
(precedingEvent)	[Reaction:R-HSA-205234] Indirect recruitment of GAB2 to p-KIT [Reaction:R-HSA-1433471] Activation of RAS by p-KIT bound SOS1