Reactome | Imatinib-resistant KIT mutants

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Imatinib-resistant KIT mutants Show undefined attributes

authored	[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
created	[InstanceEdit:9669918] Rothfels, Karen, 2019-12-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9669917
disease	[Disease:1500689] cancer
displayName	Imatinib-resistant KIT mutants
edited	[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
eventOf	[Pathway:R-HSA-9669937] Drug resistance of KIT mutants - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9669859] Imatinib-resistant KIT mutants do not bind imatinib - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9669094] Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours [LiteratureReference:9669259] The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders [LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases [LiteratureReference:9673518] Gastrointestinal stromal tumours: origin and molecular oncology
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Imatinib-resistant KIT mutants
normalPathway	[Pathway:R-HSA-1433557] Signaling by SCF-KIT
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9678239] Serrano, C�sar, 2020-03-13 [InstanceEdit:9678232] Garc�a-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9669917
summation	[Summation:9671481] Imatinib is approved for treatment of cancers carrying prima...

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[Pathway:R-HSA-9669937] Drug resistance of KIT mutants

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