Reactome | Interaction of other adapter proteins with p-KIT

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Interaction of other adapter proteins with p-KIT Show undefined attributes

authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1433498] Garapati, P V, 2011-07-11
dbId	1433501
displayName	Interaction of other adapter proteins with p-KIT
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
eventOf	[Pathway:R-HSA-1433557] Signaling by SCF-KIT - Homo sapiens
input	[DefinedSet:R-HSA-1433422] Adapter proteins [cytosol] [Complex:R-HSA-205310] p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:205327] Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor [LiteratureReference:1433522] Role for the adaptor protein Grb10 in the activation of Akt [LiteratureReference:1433544] Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc [LiteratureReference:205186] Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor [LiteratureReference:1433483] Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Interaction of other adapter proteins with p-KIT
orthologousEvent	[Reaction:R-GGA-1433501] Interaction of other adapter proteins with p-KIT - Gallus gallus [Reaction:R-XTR-1433501] Interaction of other adapter proteins with p-KIT - Xenopus tropicalis [Reaction:R-DRE-1433501] Interaction of other adapter proteins with p-KIT - Danio rerio [Reaction:R-SSC-1433501] Interaction of other adapter proteins with p-KIT - Sus scrofa [Reaction:R-BTA-1433501] Interaction of other adapter proteins with p-KIT - Bos taurus [Reaction:R-CFA-1433501] Interaction of other adapter proteins with p-KIT - Canis familiaris [Reaction:R-RNO-1433501] Interaction of other adapter proteins with p-KIT - Rattus norvegicus [Reaction:R-MMU-1433501] Interaction of other adapter proteins with p-KIT - Mus musculus
output	[Complex:R-HSA-1433538] Adapter proteins:p-KIT complex [plasma membrane]
precedingEvent	[Reaction:R-HSA-205289] Autophosphorylation of KIT - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1433501
summation	[Summation:1433425] Adapter proteins GADS, GRAP, GRB7 and GRB10 interact with ac...

Referrals

(hasEvent)

[Pathway:R-HSA-1433557] Signaling by SCF-KIT