Reactome | Signaling by SCF-KIT

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Signaling by SCF-KIT Show undefined attributes

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10994449
displayName	Signaling by SCF-KIT
eventOf	[Pathway:R-CEL-9006934] Signaling by Receptor Tyrosine Kinases - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CEL-1433514] Synthesis of PIP3 from PIP2 by PI3K - Caenorhabditis elegans [Reaction:R-CEL-1433415] Activation of RAC1 - Caenorhabditis elegans [Reaction:R-CEL-1433471] Activation of RAS by p-KIT bound SOS1 - Caenorhabditis elegans [Pathway:R-CEL-1433559] Regulation of KIT signaling - Caenorhabditis elegans [Reaction:R-CEL-1433423] PTP-RO interacts with p-c-Kit complex - Caenorhabditis elegans [Reaction:R-CEL-9669854] KIT binds type II TKIs - Caenorhabditis elegans [Reaction:R-CEL-9681375] KIT binds ripretinib - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-1433557] Signaling by SCF-KIT - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Signaling by SCF-KIT
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-1433557
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9006934] Signaling by Receptor Tyrosine Kinases
(hasEncapsulatedEvent)	[Pathway:R-CEL-1257604] PIP3 activates AKT signaling [Pathway:R-CEL-5673001] RAF/MAP kinase cascade
(inferredTo)	[Pathway:R-HSA-1433557] Signaling by SCF-KIT

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