Reactome | Nilotinib-resistant KIT mutants

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Nilotinib-resistant KIT mutants Show undefined attributes

authored	[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
created	[InstanceEdit:9669927] Rothfels, Karen, 2019-12-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9669926
disease	[Disease:1500689] cancer
displayName	Nilotinib-resistant KIT mutants
edited	[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
eventOf	[Pathway:R-HSA-9669937] Drug resistance of KIT mutants - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9669868] Nilotinib-resistant KIT mutants do not bind nilotinib - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9680569] Novel Insights into the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors [LiteratureReference:9671457] The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: Implications for drug design [LiteratureReference:9669094] Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours [LiteratureReference:9671438] Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor [LiteratureReference:9671417] Resistance to c-KIT kinase inhibitors conferred by V654A mutation
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Nilotinib-resistant KIT mutants
normalPathway	[Pathway:R-HSA-1433557] Signaling by SCF-KIT
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9678239] Serrano, C�sar, 2020-03-13 [InstanceEdit:9678232] Garc�a-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9669926
summation	[Summation:9671480] Nilotinib is a type II tyrosine kinase inhibitor currently i...

Referrals

(hasEvent)

[Pathway:R-HSA-9669937] Drug resistance of KIT mutants