Reactome | Direct recruitment of PI3K to p-KIT

Schema > Reaction > Entries

Direct recruitment of PI3K to p-KIT Show undefined attributes

authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:205198] Garapati, P V, 2007-12-10 09:55:47
dbId	205262
diseaseReaction	[Reaction:R-HSA-9670431] Phosphorylated KIT mutants bind PI3K - Homo sapiens
displayName	Direct recruitment of PI3K to p-KIT
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
eventOf	[Pathway:R-HSA-1433557] Signaling by SCF-KIT - Homo sapiens
followingEvent	[Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K - Homo sapiens [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
input	[Complex:R-HSA-205310] p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] [Complex:R-HSA-198379] PI3K alpha [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1433318] Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant [LiteratureReference:1433283] Signal transduction via the stem cell factor receptor/c-Kit [LiteratureReference:1433408] Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Direct recruitment of PI3K to p-KIT
orthologousEvent	[Reaction:R-BTA-205262] Direct recruitment of PI3K to p-KIT - Bos taurus [Reaction:R-GGA-205262] Direct recruitment of PI3K to p-KIT - Gallus gallus [Reaction:R-XTR-205262] Direct recruitment of PI3K to p-KIT - Xenopus tropicalis [Reaction:R-DRE-205262] Direct recruitment of PI3K to p-KIT - Danio rerio [Reaction:R-SSC-205262] Direct recruitment of PI3K to p-KIT - Sus scrofa [Reaction:R-CFA-205262] Direct recruitment of PI3K to p-KIT - Canis familiaris [Reaction:R-RNO-205262] Direct recruitment of PI3K to p-KIT - Rattus norvegicus [Reaction:R-MMU-205262] Direct recruitment of PI3K to p-KIT - Mus musculus
output	[Complex:R-HSA-205177] PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane]
precedingEvent	[Reaction:R-HSA-205289] Autophosphorylation of KIT - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-205262
summation	[Summation:205272] The regulatory subunit (p85) of PI3K interacts directly with...

Referrals

(normalReaction)	[Reaction:R-HSA-9670431] Phosphorylated KIT mutants bind PI3K
(hasEvent)	[Pathway:R-HSA-1433557] Signaling by SCF-KIT
(precedingEvent)	[Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3