Reactome | Interaction of KIT and sSCF

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Interaction of KIT and sSCF Show undefined attributes

authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:205198] Garapati, P V, 2007-12-10 09:55:47
dbId	205321
displayName	Interaction of KIT and sSCF
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
eventOf	[Pathway:R-HSA-1433557] Signaling by SCF-KIT - Homo sapiens
followingEvent	[Reaction:R-HSA-205231] Dimerization of KIT upon SCF binding - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-197662] KIT [plasma membrane] [Complex:R-HSA-1433307] sSCF dimer [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1433286] Expression of the Kit and KitA receptor isoforms in human acute myelogenous leukemia [LiteratureReference:1433267] Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts [LiteratureReference:1433334] Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor [LiteratureReference:1433383] Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation [LiteratureReference:1433309] Kit receptor dimerization is driven by bivalent binding of stem cell factor [LiteratureReference:1433258] Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, Kit [LiteratureReference:1433361] Epitope mapping and immunoneutralization of recombinant human stem-cell factor [LiteratureReference:1433277] Structure-function relationships of stem cell factor: an analysis based on a series of human-murine stem cell factor chimera and the mapping of a neutralizing monoclonal antibody [LiteratureReference:1433300] Structure of a c-kit product complex reveals the basis for kinase transactivation [LiteratureReference:205164] A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses [LiteratureReference:205170] Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor [LiteratureReference:205261] Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Interaction of KIT and sSCF
orthologousEvent	[Reaction:R-BTA-205321] Interaction of KIT and sSCF - Bos taurus [Reaction:R-GGA-205321] Interaction of KIT and sSCF - Gallus gallus [Reaction:R-XTR-205321] Interaction of KIT and sSCF - Xenopus tropicalis [Reaction:R-DRE-205321] Interaction of KIT and sSCF - Danio rerio [Reaction:R-SSC-205321] Interaction of KIT and sSCF - Sus scrofa [Reaction:R-CFA-205321] Interaction of KIT and sSCF - Canis familiaris [Reaction:R-RNO-205321] Interaction of KIT and sSCF - Rattus norvegicus [Reaction:R-MMU-205321] Interaction of KIT and sSCF - Mus musculus
output	[Complex:R-HSA-205166] KIT:sSCF dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-1433395] Dimerization of sSCF - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-205321
summation	[Summation:1433356] Two human isoforms of KIT have been identified, resulting fr...

Referrals

(hasEvent)	[Pathway:R-HSA-1433557] Signaling by SCF-KIT
(precedingEvent)	[Reaction:R-HSA-205231] Dimerization of KIT upon SCF binding

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