Reactome | Phosphorylation and activation of VAV1

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Phosphorylation and activation of VAV1 Show undefined attributes

authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
catalystActivity	[CatalystActivity:1433444] protein tyrosine kinase activity of SFKs:p-KIT complex [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643653] protein tyrosine kinase activity of SFKs:p-KIT complex [plasma membrane] Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1433498] Garapati, P V, 2011-07-11
dbId	1433542
displayName	Phosphorylation and activation of VAV1
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
eventOf	[Pathway:R-HSA-1433557] Signaling by SCF-KIT - Homo sapiens
followingEvent	[Reaction:R-HSA-1433415] Activation of RAC1 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-195066] VAV1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1433437] Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells [LiteratureReference:1433355] Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylation and activation of VAV1
orthologousEvent	[Reaction:R-GGA-1433542] Phosphorylation and activation of VAV1 - Gallus gallus [Reaction:R-XTR-1433542] Phosphorylation and activation of VAV1 - Xenopus tropicalis [Reaction:R-SSC-1433542] Phosphorylation and activation of VAV1 - Sus scrofa [Reaction:R-BTA-1433542] Phosphorylation and activation of VAV1 - Bos taurus [Reaction:R-CFA-1433542] Phosphorylation and activation of VAV1 - Canis familiaris [Reaction:R-RNO-1433542] Phosphorylation and activation of VAV1 - Rattus norvegicus [Reaction:R-MMU-1433542] Phosphorylation and activation of VAV1 - Mus musculus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1433526] p-VAV1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K - Homo sapiens [Reaction:R-HSA-205205] Interaction of Src family kinases with p-KIT - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1433542
summation	[Summation:1433482] The Src and PI3-kinase signaling pathways converge to activa...

Referrals

(hasEvent)	[Pathway:R-HSA-1433557] Signaling by SCF-KIT
(precedingEvent)	[Reaction:R-HSA-1433415] Activation of RAC1