Reactome | KIT binds ripretinib

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KIT binds ripretinib Show undefined attributes

authored	[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9681376] Rothfels, Karen, 2020-04-01
dbId	9681375
diseaseReaction	[Reaction:R-HSA-9681382] KIT mutants bind ripretinib - Homo sapiens
displayName	KIT binds ripretinib
edited	[InstanceEdit:9689924] Rothfels, Karen, 2020-05-22
eventOf	[Pathway:R-HSA-1433557] Signaling by SCF-KIT - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-197662] KIT [plasma membrane] [ChemicalDrug:R-ALL-9674322] ripretinib [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9674274] Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	KIT binds ripretinib
orthologousEvent	[Reaction:R-DME-9681375] KIT binds ripretinib - Drosophila melanogaster [Reaction:R-CEL-9681375] KIT binds ripretinib - Caenorhabditis elegans [Reaction:R-GGA-9681375] KIT binds ripretinib - Gallus gallus [Reaction:R-XTR-9681375] KIT binds ripretinib - Xenopus tropicalis [Reaction:R-DRE-9681375] KIT binds ripretinib - Danio rerio [Reaction:R-SSC-9681375] KIT binds ripretinib - Sus scrofa [Reaction:R-BTA-9681375] KIT binds ripretinib - Bos taurus [Reaction:R-CFA-9681375] KIT binds ripretinib - Canis familiaris [Reaction:R-RNO-9681375] KIT binds ripretinib - Rattus norvegicus [Reaction:R-MMU-9681375] KIT binds ripretinib - Mus musculus
output	[Complex:R-HSA-9681373] KIT:ripretinib [plasma membrane]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9678239] Serrano, C�sar, 2020-03-13 [InstanceEdit:9678232] Garc�a-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9681375
summation	[Summation:9681377] Ripretinib is a example of a switch pocket inhibitor, a new ...
updateTrackers	[UpdateTracker:9775279] Update Tracker - [Reaction:9681375] KIT binds ripretinib - v79:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775279] Update Tracker - [Reaction:9681375] KIT binds ripretinib - v79:[modifyText]
(normalReaction)	[Reaction:R-HSA-9681382] KIT mutants bind ripretinib
(hasEvent)	[Pathway:R-HSA-1433557] Signaling by SCF-KIT