Reactome | Phosphorylation of SHP2 by SFKs

Schema > Reaction > Entries

Phosphorylation of SHP2 by SFKs Show undefined attributes

authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
catalystActivity	[CatalystActivity:1433495] protein tyrosine kinase activity of SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643977] protein tyrosine kinase activity of SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1433498] Garapati, P V, 2011-07-11
dbId	1433488
displayName	Phosphorylation of SHP2 by SFKs
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
eventOf	[Pathway:R-HSA-1433557] Signaling by SCF-KIT - Homo sapiens
followingEvent	[Reaction:R-HSA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-205267] SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:205299] The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylation of SHP2 by SFKs
orthologousEvent	[Reaction:R-GGA-1433488] Phosphorylation of SHP2 by SFKs - Gallus gallus [Reaction:R-XTR-1433488] Phosphorylation of SHP2 by SFKs - Xenopus tropicalis [Reaction:R-DRE-1433488] Phosphorylation of SHP2 by SFKs - Danio rerio [Reaction:R-SSC-1433488] Phosphorylation of SHP2 by SFKs - Sus scrofa [Reaction:R-BTA-1433488] Phosphorylation of SHP2 by SFKs - Bos taurus [Reaction:R-CFA-1433488] Phosphorylation of SHP2 by SFKs - Canis familiaris [Reaction:R-RNO-1433488] Phosphorylation of SHP2 by SFKs - Rattus norvegicus [Reaction:R-MMU-1433488] Phosphorylation of SHP2 by SFKs - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1433530] p-SHP2:p-KIT complex [plasma membrane]
precedingEvent	[Reaction:R-HSA-205238] SHP2 interacts with p-KIT - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1433488
summation	[Summation:1433463] Following association with KIT, Tauchi et al. had observed p...

Referrals

(hasEvent)	[Pathway:R-HSA-1433557] Signaling by SCF-KIT
(precedingEvent)	[Reaction:R-HSA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2