Reactome | MAL [mitochondrial matrix]

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MAL [mitochondrial matrix] Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix
consumedByEvent	[Reaction:R-GGA-373141] malate <=> fumarate + H2O - Gallus gallus [Reaction:R-GGA-373047] malate + NAD+ <=> oxaloacetate + NADH + H+ - Gallus gallus [Reaction:R-GGA-372852] malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] - Gallus gallus [Reaction:R-PFA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Plasmodium falciparum [Reaction:R-DRE-9012268] ME2 tetramer decarboxylates MAL to PYR - Danio rerio [Reaction:R-SCE-372843] SLC25A10 mediates exchange of malate and phosphate - Saccharomyces cerevisiae [Reaction:R-DDI-372843] SLC25A10 mediates exchange of malate and phosphate - Dictyostelium discoideum [Reaction:R-CEL-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Caenorhabditis elegans [Reaction:R-CEL-372843] SLC25A10 mediates exchange of malate and phosphate - Caenorhabditis elegans [Reaction:R-DME-372843] SLC25A10 mediates exchange of malate and phosphate - Drosophila melanogaster [Reaction:R-DME-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Drosophila melanogaster [Reaction:R-GGA-372843] SLC25A10 mediates exchange of malate and phosphate - Gallus gallus [Reaction:R-XTR-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Xenopus tropicalis [Reaction:R-XTR-372843] SLC25A10 mediates exchange of malate and phosphate - Xenopus tropicalis [Reaction:R-DRE-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Danio rerio [Reaction:R-DRE-372843] SLC25A10 mediates exchange of malate and phosphate - Danio rerio [Reaction:R-SSC-372843] SLC25A10 mediates exchange of malate and phosphate - Sus scrofa [Reaction:R-SSC-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Sus scrofa [Reaction:R-BTA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Bos taurus [Reaction:R-BTA-372843] SLC25A10 mediates exchange of malate and phosphate - Bos taurus [Reaction:R-CFA-372843] SLC25A10 mediates exchange of malate and phosphate - Canis familiaris [Reaction:R-CFA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Canis familiaris [Reaction:R-RNO-372843] SLC25A10 mediates exchange of malate and phosphate - Rattus norvegicus [Reaction:R-RNO-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Rattus norvegicus [Reaction:R-MMU-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Mus musculus [Reaction:R-MMU-372843] SLC25A10 mediates exchange of malate and phosphate - Mus musculus [Reaction:R-GGA-9012268] ME2 tetramer decarboxylates MAL to PYR - Gallus gallus [Reaction:R-GGA-9012349] ME3 tetramer decarboxylates MAL to PYR - Gallus gallus [Reaction:R-PFA-70979] MDH2 dimer dehydrogenates MAL - Plasmodium falciparum [Reaction:R-SCE-70979] MDH2 dimer dehydrogenates MAL - Saccharomyces cerevisiae [Reaction:R-SPO-70979] MDH2 dimer dehydrogenates MAL - Schizosaccharomyces pombe [Reaction:R-CEL-9012268] ME2 tetramer decarboxylates MAL to PYR - Caenorhabditis elegans [Reaction:R-CEL-70979] MDH2 dimer dehydrogenates MAL - Caenorhabditis elegans [Reaction:R-CEL-9012349] ME3 tetramer decarboxylates MAL to PYR - Caenorhabditis elegans [Reaction:R-MMU-9012268] ME2 tetramer decarboxylates MAL to PYR - Mus musculus [Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens [Reaction:R-HSA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Homo sapiens [Reaction:R-HSA-372843] SLC25A10 mediates exchange of malate and phosphate - Homo sapiens [Reaction:R-MMU-70979] MDH2 dimer dehydrogenates MAL - Mus musculus [Reaction:R-RNO-9012268] ME2 tetramer decarboxylates MAL to PYR - Rattus norvegicus [Reaction:R-RNO-70979] MDH2 dimer dehydrogenates MAL - Rattus norvegicus [Reaction:R-CFA-70979] MDH2 dimer dehydrogenates MAL - Canis familiaris [Reaction:R-CFA-9012268] ME2 tetramer decarboxylates MAL to PYR - Canis familiaris [Reaction:R-HSA-9012268] ME2 tetramer decarboxylates MAL to PYR - Homo sapiens [Reaction:R-BTA-9012268] ME2 tetramer decarboxylates MAL to PYR - Bos taurus [Reaction:R-BTA-70979] MDH2 dimer dehydrogenates MAL - Bos taurus [Reaction:R-BTA-9012349] ME3 tetramer decarboxylates MAL to PYR - Bos taurus [Reaction:R-HSA-9012349] ME3 tetramer decarboxylates MAL to PYR - Homo sapiens [Reaction:R-MMU-9012349] ME3 tetramer decarboxylates MAL to PYR - Mus musculus [Reaction:R-RNO-9012349] ME3 tetramer decarboxylates MAL to PYR - Rattus norvegicus [Reaction:R-CFA-9012349] ME3 tetramer decarboxylates MAL to PYR - Canis familiaris [Reaction:R-SSC-9012349] ME3 tetramer decarboxylates MAL to PYR - Sus scrofa [Reaction:R-DRE-9012349] ME3 tetramer decarboxylates MAL to PYR - Danio rerio [Reaction:R-SSC-70979] MDH2 dimer dehydrogenates MAL - Sus scrofa [Reaction:R-SSC-9012268] ME2 tetramer decarboxylates MAL to PYR - Sus scrofa [Reaction:R-XTR-9012268] ME2 tetramer decarboxylates MAL to PYR - Xenopus tropicalis [Reaction:R-XTR-9012349] ME3 tetramer decarboxylates MAL to PYR - Xenopus tropicalis [Reaction:R-XTR-70979] MDH2 dimer dehydrogenates MAL - Xenopus tropicalis [Reaction:R-DRE-70979] MDH2 dimer dehydrogenates MAL - Danio rerio [Reaction:R-DME-70979] MDH2 dimer dehydrogenates MAL - Drosophila melanogaster [Reaction:R-DME-9012349] ME3 tetramer decarboxylates MAL to PYR - Drosophila melanogaster [Reaction:R-DME-9012268] ME2 tetramer decarboxylates MAL to PYR - Drosophila melanogaster [Reaction:R-GGA-70979] MDH2 dimer dehydrogenates MAL - Gallus gallus
created	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
crossReference	[DatabaseIdentifier:29637] COMPOUND:C00149
dbId	113544
displayName	MAL [mitochondrial matrix]
inDisease	false
maxDepth	1
modified	[InstanceEdit:9760981] D'Eustachio, Peter, 2022-01-05
name	MAL (S)-Malate (S)-malic acid L-Malate L-Apple acid L-Malic acid L-2-Hydroxybutanedioic acid
negativelyRegulates	[NegativeRegulation:9986301] Negative regulation by 'MAL [mitochondrial matrix]' [NegativeRegulation:9861847] Negative regulation by 'MAL [mitochondrial matrix]'
producedByEvent	[Reaction:R-GGA-376887] 2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] - Gallus gallus [Reaction:R-GGA-372422] oxaloacetate + NADH + H+ <=> malate + NAD+ - Gallus gallus [Reaction:R-GGA-373145] fumarate + H2O <=> malate - Gallus gallus [Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL - Homo sapiens [Reaction:R-CFA-376851] SLC25A11 exchanges 2-OG and MAL - Canis familiaris [Reaction:R-SCE-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Saccharomyces cerevisiae [Reaction:R-DDI-70982] FH tetramer hydrates fumarate to L-malate - Dictyostelium discoideum [Reaction:R-DDI-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Dictyostelium discoideum [Reaction:R-CEL-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Caenorhabditis elegans [Reaction:R-DME-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Drosophila melanogaster [Reaction:R-GGA-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Gallus gallus [Reaction:R-XTR-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Xenopus tropicalis [Reaction:R-DRE-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Danio rerio [Reaction:R-SSC-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Sus scrofa [Reaction:R-BTA-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Bos taurus [Reaction:R-CFA-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Canis familiaris [Reaction:R-RNO-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Rattus norvegicus [Reaction:R-HSA-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Homo sapiens [Reaction:R-MMU-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Mus musculus [Reaction:R-DME-376851] SLC25A11 exchanges 2-OG and MAL - Drosophila melanogaster [Reaction:R-PFA-376851] SLC25A11 exchanges 2-OG and MAL - Plasmodium falciparum [Reaction:R-SCE-70982] FH tetramer hydrates fumarate to L-malate - Saccharomyces cerevisiae [Reaction:R-SPO-70982] FH tetramer hydrates fumarate to L-malate - Schizosaccharomyces pombe [Reaction:R-CEL-376851] SLC25A11 exchanges 2-OG and MAL - Caenorhabditis elegans [Reaction:R-CEL-70982] FH tetramer hydrates fumarate to L-malate - Caenorhabditis elegans [Reaction:R-GGA-70982] FH tetramer hydrates fumarate to L-malate - Gallus gallus [Reaction:R-MMU-70982] FH tetramer hydrates fumarate to L-malate - Mus musculus [Reaction:R-HSA-70982] FH tetramer hydrates fumarate to L-malate - Homo sapiens [Reaction:R-MMU-376851] SLC25A11 exchanges 2-OG and MAL - Mus musculus [Reaction:R-RNO-70982] FH tetramer hydrates fumarate to L-malate - Rattus norvegicus [Reaction:R-RNO-376851] SLC25A11 exchanges 2-OG and MAL - Rattus norvegicus [Reaction:R-CFA-70982] FH tetramer hydrates fumarate to L-malate - Canis familiaris [Reaction:R-BTA-70982] FH tetramer hydrates fumarate to L-malate - Bos taurus [Reaction:R-BTA-376851] SLC25A11 exchanges 2-OG and MAL - Bos taurus [Reaction:R-DRE-70982] FH tetramer hydrates fumarate to L-malate - Danio rerio [Reaction:R-SSC-376851] SLC25A11 exchanges 2-OG and MAL - Sus scrofa [Reaction:R-XTR-376851] SLC25A11 exchanges 2-OG and MAL - Xenopus tropicalis [Reaction:R-DRE-376851] SLC25A11 exchanges 2-OG and MAL - Danio rerio [Reaction:R-DME-70982] FH tetramer hydrates fumarate to L-malate - Drosophila melanogaster [Reaction:R-SPO-75849] SLC25A1 exchanges CIT and MAL - Schizosaccharomyces pombe [Reaction:R-SCE-75849] SLC25A1 exchanges CIT and MAL - Saccharomyces cerevisiae [Reaction:R-CEL-75849] SLC25A1 exchanges CIT and MAL - Caenorhabditis elegans [Reaction:R-DME-75849] SLC25A1 exchanges CIT and MAL - Drosophila melanogaster [Reaction:R-GGA-75849] SLC25A1 exchanges CIT and MAL - Gallus gallus [Reaction:R-XTR-75849] SLC25A1 exchanges CIT and MAL - Xenopus tropicalis [Reaction:R-DRE-75849] SLC25A1 exchanges CIT and MAL - Danio rerio [Reaction:R-SSC-75849] SLC25A1 exchanges CIT and MAL - Sus scrofa [Reaction:R-BTA-75849] SLC25A1 exchanges CIT and MAL - Bos taurus [Reaction:R-CFA-75849] SLC25A1 exchanges CIT and MAL - Canis familiaris [Reaction:R-RNO-75849] SLC25A1 exchanges CIT and MAL - Rattus norvegicus [Reaction:R-MMU-75849] SLC25A1 exchanges CIT and MAL - Mus musculus [Reaction:R-HSA-75849] SLC25A1 exchanges CIT and MAL - Homo sapiens
referenceEntity	[ReferenceMolecule:chebi:15589] (S)-malate(2-) [ChEBI:15589]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-113544
updateTrackers	[UpdateTracker:9890904] Update Tracker - [SimpleEntity:113544] MAL [mitochondrial matrix] - v52:[addName] [UpdateTracker:9903241] Update Tracker - [SimpleEntity:113544] MAL [mitochondrial matrix] - v80:[add_removeReferenceEntity] [UpdateTracker:9874503] Update Tracker - [SimpleEntity:113544] MAL [mitochondrial matrix] - v43:[addName]

Referrals

(input)	[Reaction:R-GGA-373141] malate <=> fumarate + H2O [Reaction:R-GGA-373047] malate + NAD+ <=> oxaloacetate + NADH + H+ [Reaction:R-GGA-372852] malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] [Reaction:R-PFA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-DRE-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-SCE-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-DDI-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-CEL-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-CEL-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-DME-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-DME-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-GGA-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-XTR-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-XTR-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-DRE-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-DRE-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-SSC-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-SSC-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-BTA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-BTA-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-CFA-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-CFA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-RNO-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-RNO-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-MMU-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-MMU-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-GGA-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-GGA-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-PFA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-SCE-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-SPO-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-CEL-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-CEL-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-CEL-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-MMU-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-HSA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-HSA-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-MMU-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-RNO-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-RNO-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-CFA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-CFA-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-HSA-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-BTA-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-BTA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-BTA-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-HSA-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-MMU-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-RNO-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-CFA-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-SSC-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-DRE-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-SSC-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-SSC-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-XTR-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-XTR-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-XTR-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-DRE-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-DME-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-DME-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-DME-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-GGA-70979] MDH2 dimer dehydrogenates MAL
(output)	[Reaction:R-GGA-376887] 2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] [Reaction:R-GGA-372422] oxaloacetate + NADH + H+ <=> malate + NAD+ [Reaction:R-GGA-373145] fumarate + H2O <=> malate [Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-SPO-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-CFA-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-SCE-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-SCE-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-DDI-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-DDI-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-CEL-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-CEL-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-DME-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-DME-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-GGA-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-GGA-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-XTR-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-XTR-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-DRE-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-DRE-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-SSC-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-SSC-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-BTA-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-BTA-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-CFA-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-CFA-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-RNO-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-RNO-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-HSA-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-MMU-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-MMU-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-DME-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-PFA-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-SCE-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-SPO-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-CEL-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-CEL-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-GGA-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-MMU-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-HSA-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-HSA-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-MMU-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-RNO-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-RNO-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-CFA-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-BTA-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-BTA-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-DRE-70982] FH tetramer hydrates fumarate to L-malate [Reaction:R-SSC-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-XTR-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-DRE-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-DME-70982] FH tetramer hydrates fumarate to L-malate
(regulator)	[NegativeRegulation:9986301] Negative regulation by 'MAL [mitochondrial matrix]' [NegativeRegulation:9861847] Negative regulation by 'MAL [mitochondrial matrix]'
(updatedInstance)	[UpdateTracker:9890904] Update Tracker - [SimpleEntity:113544] MAL [mitochondrial matrix] - v52:[addName] [UpdateTracker:9903241] Update Tracker - [SimpleEntity:113544] MAL [mitochondrial matrix] - v80:[add_removeReferenceEntity] [UpdateTracker:9874503] Update Tracker - [SimpleEntity:113544] MAL [mitochondrial matrix] - v43:[addName]

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