Reactome | SLC25A11 exchanges 2-OG and MAL

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SLC25A11 exchanges 2-OG and MAL Show undefined attributes

catalystActivity	[CatalystActivity:10498607] oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
dbId	10502813
displayName	SLC25A11 exchanges 2-OG and MAL
eventOf	[Pathway:R-XTR-9856872] Malate-aspartate shuttle - Xenopus tropicalis
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-70979] MDH2 dimer dehydrogenates MAL - Xenopus tropicalis [Reaction:R-XTR-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-198498] MAL [cytosol]
isInDisease	false
isInferred	true
name	SLC25A11 exchanges 2-OG and MAL SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (S)-malate(out) + 2-oxoglutarate(in) => (S)-malate(in) + 2-oxoglutarate(out)
output	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-9856871] MDH1 reduces OA - Xenopus tropicalis [Reaction:R-XTR-70613] GOT2 transaminates OA and L-Glu - Xenopus tropicalis
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-376851
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9856872] Malate-aspartate shuttle
(precedingEvent)	[Reaction:R-XTR-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-XTR-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp
(inferredTo)	[Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL

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