Reactome | SLC25A10 mediates exchange of malate and phosphate

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SLC25A10 mediates exchange of malate and phosphate Show undefined attributes

catalystActivity	[CatalystActivity:11087607] dicarboxylic acid transmembrane transporter activity of SLC25A10 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11087609
displayName	SLC25A10 mediates exchange of malate and phosphate
eventOf	[Pathway:R-SCE-428643] Organic anion transport by SLC5/17/25 transporters - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Saccharomyces cerevisiae [Reaction:R-SCE-75849] SLC25A1 exchanges CIT and MAL - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-372843] SLC25A10 mediates exchange of malate and phosphate - Homo sapiens
input	[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix] [SimpleEntity:R-ALL-29372] Pi [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC25A10 mediates exchange of malate and phosphate (S)-malate(in) + phosphate(out) => (S)-malate(out) + phosphate(in)
output	[SimpleEntity:R-ALL-198498] MAL [cytosol] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-SCE-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Saccharomyces cerevisiae [Reaction:R-SCE-70982] FH tetramer hydrates fumarate to L-malate - Saccharomyces cerevisiae [Reaction:R-SCE-75849] SLC25A1 exchanges CIT and MAL - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-372843
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-428643] Organic anion transport by SLC5/17/25 transporters
(precedingEvent)	[Reaction:R-SCE-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate [Reaction:R-SCE-75849] SLC25A1 exchanges CIT and MAL
(inferredTo)	[Reaction:R-HSA-372843] SLC25A10 mediates exchange of malate and phosphate

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