Reactome | Sulfate is exported to the cytosol in exchange for dicarboxylate

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Sulfate is exported to the cytosol in exchange for dicarboxylate Show undefined attributes

catalystActivity	[CatalystActivity:10249074] dicarboxylic acid transmembrane transporter activity of SLC25A10 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:70101] cytosol [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10270283
displayName	Sulfate is exported to the cytosol in exchange for dicarboxylate
eventOf	[Pathway:R-CFA-428643] Organic anion transport by SLC5/17/25 transporters - Canis familiaris [Pathway:R-CFA-1614517] Sulfide oxidation to sulfate - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-372843] SLC25A10 mediates exchange of malate and phosphate - Canis familiaris [Reaction:R-CFA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Canis familiaris
inferredFrom	[Reaction:R-HSA-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Homo sapiens
input	[SimpleEntity:R-ALL-198498] MAL [cytosol] [SimpleEntity:R-ALL-1614584] SO4(2-) [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	Sulfate is exported to the cytosol in exchange for dicarboxylate (S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in)
output	[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix] [SimpleEntity:R-ALL-174375] SO4(2-) [cytosol]
precedingEvent	[Reaction:R-CFA-1614544] Sulfite is oxidized to sulfate - Canis familiaris [Reaction:R-CFA-372843] SLC25A10 mediates exchange of malate and phosphate - Canis familiaris [Reaction:R-CFA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1614546
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-428643] Organic anion transport by SLC5/17/25 transporters [Pathway:R-CFA-1614517] Sulfide oxidation to sulfate
(inferredTo)	[Reaction:R-HSA-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate
(precedingEvent)	[Reaction:R-CFA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-CFA-372843] SLC25A10 mediates exchange of malate and phosphate