Reactome | SLC25A1 exchanges CIT and MAL

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SLC25A1 exchanges CIT and MAL Show undefined attributes

catalystActivity	[CatalystActivity:372450] tricarboxylic acid transmembrane transporter activity of SLC25A1 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:75111] Gopinathrao, G, 2003-09-07 15:00:00
crossReference	[DatabaseIdentifier:12667545] RHEA:72483 [DatabaseIdentifier:9857408] RHEA:72485
dbId	75849
displayName	SLC25A1 exchanges CIT and MAL
eventOf	[Pathway:R-HSA-428643] Organic anion transport by SLC5/17/25 transporters - Homo sapiens
followingEvent	[Reaction:R-HSA-75848] ACLY tetramer transforms CIT to Ac-CoA - Homo sapiens [Reaction:R-HSA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Homo sapiens [Reaction:R-HSA-372843] SLC25A10 mediates exchange of malate and phosphate - Homo sapiens
input	[SimpleEntity:R-ALL-29654] CIT [mitochondrial matrix] [SimpleEntity:R-ALL-198498] MAL [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8984239] The mitochondrial citrate carrier: metabolic role and regulation of its activity and expression [LiteratureReference:8984206] Agenesis of corpus callosum and optic nerve hypoplasia due to mutations in SLC25A1 encoding the mitochondrial citrate transporter [LiteratureReference:9854271] Pathogenic mutations of the human mitochondrial citrate carrier SLC25A1 lead to impaired citrate export required for lipid, dolichol, ubiquinone and sterol synthesis [LiteratureReference:9854284] Insights into the malfunctioning of the mitochondrial citrate carrier: Implications for cell pathology [LiteratureReference:9854280] Multiple roles played by the mitochondrial citrate carrier in cellular metabolism and physiology [LiteratureReference:9857402] Determiners of cell fates: the tricarboxylic acid cycle versus the citrate-malate shuttle [LiteratureReference:9857411] Mutations in the Mitochondrial Citrate Carrier SLC25A1 are Associated with Impaired Neuromuscular Transmission
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SLC25A1 exchanges CIT and MAL SLC25A1 exports citrate from mitochondrion in exchange for malate Transport of Citrate from Mitochondrial Matrix to cytosol
orthologousEvent	[Reaction:R-SPO-75849] SLC25A1 exchanges CIT and MAL - Schizosaccharomyces pombe [Reaction:R-MMU-75849] SLC25A1 exchanges CIT and MAL - Mus musculus [Reaction:R-SCE-75849] SLC25A1 exchanges CIT and MAL - Saccharomyces cerevisiae [Reaction:R-CEL-75849] SLC25A1 exchanges CIT and MAL - Caenorhabditis elegans [Reaction:R-DME-75849] SLC25A1 exchanges CIT and MAL - Drosophila melanogaster [Reaction:R-GGA-75849] SLC25A1 exchanges CIT and MAL - Gallus gallus [Reaction:R-XTR-75849] SLC25A1 exchanges CIT and MAL - Xenopus tropicalis [Reaction:R-DRE-75849] SLC25A1 exchanges CIT and MAL - Danio rerio [Reaction:R-SSC-75849] SLC25A1 exchanges CIT and MAL - Sus scrofa [Reaction:R-BTA-75849] SLC25A1 exchanges CIT and MAL - Bos taurus [Reaction:R-CFA-75849] SLC25A1 exchanges CIT and MAL - Canis familiaris [Reaction:R-RNO-75849] SLC25A1 exchanges CIT and MAL - Rattus norvegicus
output	[SimpleEntity:R-ALL-76190] CIT [cytosol] [SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Homo sapiens [Reaction:R-HSA-70975] CS acetylates OA to citrate - Homo sapiens [Reaction:R-HSA-372843] SLC25A10 mediates exchange of malate and phosphate - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-75849
summation	[Summation:179268] SLC25A1, in the inner mitochondrial membrane, mediates the e...
updateTrackers	[UpdateTracker:9790490] Update Tracker - [Reaction:75849] Transport of Citrate from Mitochondrial Matrix to cytosol - v33:[addCatalystActivity, addInput, addOutput, modifyText] [UpdateTracker:9864251] Update Tracker - [Reaction:75849] SLC25A1 exchanges CIT and MAL - v88:[addLiteratureReference, modifyText] [UpdateTracker:9781045] Update Tracker - [Reaction:75849] Transport of Citrate from Mitochondrial Matrix to cytosol - v61:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790490] Update Tracker - [Reaction:75849] Transport of Citrate from Mitochondrial Matrix to cytosol - v33:[addCatalystActivity, addInput, addOutput, modifyText] [UpdateTracker:9864251] Update Tracker - [Reaction:75849] SLC25A1 exchanges CIT and MAL - v88:[addLiteratureReference, modifyText] [UpdateTracker:9781045] Update Tracker - [Reaction:75849] Transport of Citrate from Mitochondrial Matrix to cytosol - v61:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-428643] Organic anion transport by SLC5/17/25 transporters
(precedingEvent)	[Reaction:R-HSA-75848] ACLY tetramer transforms CIT to Ac-CoA [Reaction:R-HSA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Reaction:R-HSA-372843] SLC25A10 mediates exchange of malate and phosphate

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