Reactome | SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane

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SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane Show undefined attributes

catalystActivity	[CatalystActivity:10002395] oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10002397
displayName	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
eventOf	[Pathway:R-MMU-428643] Organic anion transport by SLC5/17/25 transporters - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-75849] SLC25A1 exchanges CIT and MAL - Mus musculus [Reaction:R-MMU-9012036] ME1 tetramer decarboxylates MAL to PYR - Mus musculus [Reaction:R-MMU-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Mus musculus
inferredFrom	[Reaction:R-HSA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (S)-malate(in) + 2-oxoglutarate(out) => (S)-malate(out) + 2-oxoglutarate(in)
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-198498] MAL [cytosol]
precedingEvent	[Reaction:R-MMU-75849] SLC25A1 exchanges CIT and MAL - Mus musculus [Reaction:R-MMU-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-198440
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-428643] Organic anion transport by SLC5/17/25 transporters
(precedingEvent)	[Reaction:R-MMU-9012036] ME1 tetramer decarboxylates MAL to PYR [Reaction:R-MMU-75849] SLC25A1 exchanges CIT and MAL [Reaction:R-MMU-1614546] Sulfate is exported to the cytosol in exchange for dicarboxylate
(inferredTo)	[Reaction:R-HSA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane

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