Reactome | FH tetramer hydrates fumarate to L-malate

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FH tetramer hydrates fumarate to L-malate Show undefined attributes

catalystActivity	[CatalystActivity:10228364] fumarate hydratase activity of FH tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10228366
displayName	FH tetramer hydrates fumarate to L-malate
eventOf	[Pathway:R-CFA-71403] Citric acid cycle (TCA cycle) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-70979] MDH2 dimer dehydrogenates MAL - Canis familiaris [Reaction:R-CFA-372843] SLC25A10 mediates exchange of malate and phosphate - Canis familiaris [Reaction:R-CFA-9012349] ME3 tetramer decarboxylates MAL to PYR - Canis familiaris [Reaction:R-CFA-9012268] ME2 tetramer decarboxylates MAL to PYR - Canis familiaris
inferredFrom	[Reaction:R-HSA-70982] FH tetramer hydrates fumarate to L-malate - Homo sapiens
input	[SimpleEntity:R-ALL-113588] FUMA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	FH tetramer hydrates fumarate to L-malate fumarate + H2O => (S)-malate
output	[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
precedingEvent	[Reaction:R-CFA-70994] SDH complex dehydrogenates succinate - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-70982
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-71403] Citric acid cycle (TCA cycle)
(precedingEvent)	[Reaction:R-CFA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-CFA-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-CFA-9012349] ME3 tetramer decarboxylates MAL to PYR [Reaction:R-CFA-9012268] ME2 tetramer decarboxylates MAL to PYR
(inferredTo)	[Reaction:R-HSA-70982] FH tetramer hydrates fumarate to L-malate