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Schema
>
Reaction
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Entries
SLC25A11 exchanges 2-OG and MAL
Show undefined attributes
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authored
[InstanceEdit:377494] D'Eustachio, P, 2008-09-12 22:05:52
catalystActivity
[CatalystActivity:198502] oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane]
catalystActivityReference
[CatalystActivityReference:9815400] oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane] Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:70616] mitochondrial inner membrane
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:376857] D'Eustachio, P, 2008-09-09 21:21:16
crossReference
[DatabaseIdentifier:9856892] RHEA:71589
[DatabaseIdentifier:11880647] Rhea:71587
dbId
376851
displayName
SLC25A11 exchanges 2-OG and MAL
edited
[InstanceEdit:377494] D'Eustachio, P, 2008-09-12 22:05:52
eventOf
[Pathway:R-HSA-9856872] Malate-aspartate shuttle - Homo sapiens
followingEvent
[Reaction:R-HSA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Homo sapiens
[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens
input
[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix]
[SimpleEntity:R-ALL-198498] MAL [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:198487] Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier
[LiteratureReference:376855] The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier
[LiteratureReference:376852] Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the external-product inhibition
[LiteratureReference:9856886] The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione
[LiteratureReference:9856888] Germline Mutations in the Mitochondrial 2-Oxoglutarate/Malate Carrier
SLC25A11
Gene Confer a Predisposition to Metastatic Paragangliomas
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
SLC25A11 exchanges 2-OG and MAL
SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane
(S)-malate(out) + 2-oxoglutarate(in) => (S)-malate(in) + 2-oxoglutarate(out)
orthologousEvent
[Reaction:R-MMU-376851] SLC25A11 exchanges 2-OG and MAL - Mus musculus
[Reaction:R-PFA-376851] SLC25A11 exchanges 2-OG and MAL - Plasmodium falciparum
[Reaction:R-SSC-376851] SLC25A11 exchanges 2-OG and MAL - Sus scrofa
[Reaction:R-DRE-376851] SLC25A11 exchanges 2-OG and MAL - Danio rerio
[Reaction:R-DME-376851] SLC25A11 exchanges 2-OG and MAL - Drosophila melanogaster
[Reaction:R-CEL-376851] SLC25A11 exchanges 2-OG and MAL - Caenorhabditis elegans
[Reaction:R-GGA-376851] SLC25A11 exchanges 2-OG and MAL - Gallus gallus
[Reaction:R-XTR-376851] SLC25A11 exchanges 2-OG and MAL - Xenopus tropicalis
[Reaction:R-BTA-376851] SLC25A11 exchanges 2-OG and MAL - Bos taurus
[Reaction:R-CFA-376851] SLC25A11 exchanges 2-OG and MAL - Canis familiaris
[Reaction:R-RNO-376851] SLC25A11 exchanges 2-OG and MAL - Rattus norvegicus
output
[SimpleEntity:R-ALL-29406] 2OG [cytosol]
[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-9856871] MDH1 reduces OA - Homo sapiens
[Reaction:R-HSA-70613] GOT2 transaminates OA and L-Glu - Homo sapiens
releaseDate
2008-06-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12
[InstanceEdit:9815859] Hill, David P, 2022-08-29
revised
[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-376851
summation
[Summation:376853] The SLC25A11 transport protein in the inner mitochondrial me...
Referrals
(hasEvent)
[Pathway:R-HSA-9856872] Malate-aspartate shuttle
(precedingEvent)
[Reaction:R-HSA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp
[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL
(reverseReaction)
[Reaction:R-HSA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
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