Reactome | SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane

Schema > Reaction > Entries

SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane Show undefined attributes

authored	[InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01
catalystActivity	[CatalystActivity:198502] oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane]
catalystActivityReference	[CatalystActivityReference:9815400] oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane] Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01
crossReference	[DatabaseIdentifier:9857058] RHEA:71588 [DatabaseIdentifier:11880646] Rhea:71587
dbId	198440
displayName	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
edited	[InstanceEdit:377494] D'Eustachio, P, 2008-09-12 22:05:52
eventOf	[Pathway:R-HSA-428643] Organic anion transporters - Homo sapiens
followingEvent	[Reaction:R-HSA-9012036] ME1 tetramer decarboxylates MAL to PYR - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:198487] Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier [LiteratureReference:376855] The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier [LiteratureReference:376852] Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the external-product inhibition
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (S)-malate(in) + 2-oxoglutarate(out) => (S)-malate(out) + 2-oxoglutarate(in)
orthologousEvent	[Reaction:R-GGA-376887] 2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] - Gallus gallus [Reaction:R-PFA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Plasmodium falciparum [Reaction:R-CEL-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Caenorhabditis elegans [Reaction:R-DME-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Drosophila melanogaster [Reaction:R-GGA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Gallus gallus [Reaction:R-XTR-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Xenopus tropicalis [Reaction:R-DRE-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Danio rerio [Reaction:R-SSC-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Sus scrofa [Reaction:R-BTA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Bos taurus [Reaction:R-CFA-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Canis familiaris [Reaction:R-RNO-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Rattus norvegicus [Reaction:R-MMU-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Mus musculus
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-198498] MAL [cytosol]
releaseDate	2005-09-26
reverseReaction	[Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12 [InstanceEdit:9815859] Hill, David P, 2022-08-29
revised	[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-198440
summation	[Summation:198510] The SLC25A11 transport protein in the inner mitochondrial me...

Referrals

(hasEvent)	[Pathway:R-HSA-428643] Organic anion transporters
(precedingEvent)	[Reaction:R-HSA-9012036] ME1 tetramer decarboxylates MAL to PYR